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Fig. 5 | BMC Complementary Medicine and Therapies

Fig. 5

From: Panax quinquefolius saponin inhibits vascular smooth muscle cell calcification via activation of nuclear factor-erythroid 2-related factor 2

Fig. 5

PQS regulates the Keap1/Nrf2 pathway during high phosphate-induced vascular smooth muscle cell calcification. A VSMCs were treated with calcification medium containing 3 mM Pi for 6 days. The protein expression of Keap1 was determined using Western blot analysis. #p < 0.05 vs. Pi control. B VSMCs were transfected with Keap1 siRNA or control siRNA and further incubated with PQS in calcification medium for 6 days. The protein expression of Keap1, Nrf2 and the osteogenic marker Runx2 was determined using Western blot analysis. The values are presented as the means ± SD (n = 3). *p < 0.05 or **p < 0.01 vs. Ctrl, #p < 0.05 vs. si-Ctrl

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