Fig. 8

Schematic illustration of Nrf2 signaling pathway in oxidative stress (A) and protein network STRING (B). Nrf2-related signaling pathway plays a key role in directly regulating oxidative stress signaling pathway by overexpression of antioxidant enzymes (TrxR, SOD, GPX). Nrf2 is regulated by Keap1 in constitutive/oxidative conditions. Proteins coded light green were investigated in the present study, and those coded in dark green are bioinformatic predictions of the next layers in the network. The light green proteins was selected based theit ipmrtance in the siganling pathways, shown by the previously published reports (summerized in Table 3). The importance of these proteins were also confirmed by our by our bioinformatic analysis and pathway investigation by the String tool. A There are meaningful interactions among proteins (Nrf2, SOD, TrxR, GPX, SIRT1, AKT, P38, HIF1) based on the network and pathway analysis by STRING online tool. The different color lines show various interaction types among proteins on the system level. Dotted lines indicate inter-cluster and straight lines show cluster association (B)