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Fig. 5 | BMC Complementary Medicine and Therapies

Fig. 5

From: Prevotella histicola suppresses ferroptosis to mitigate ethanol-induced gastric mucosal lesions in mice

Fig. 5

A schematic diagram depicting the anti-ferroptosis mechanism of P. histicolaagainst EGML

P. histicola, with high colonization inits extensive colonisation of the stomach, reduced the ethanol-induced gastric mucosal lesion through lesions by downregulating ferroptosis. Treatment with P. histicola reduced the lipid peroxidation by regulating iron homeostasis-related genes, TFR1, SLC39A14 and HMOX-1, inhibiting pro-ferroptotic ACSL4- and VDAC1, 3- dependent pathways, and promoting the anti-ferropotic System Xc-/GPX4 axis

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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