Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats

Table 1 Effect of methanol extract of A. americana on biochemical parameters in paracetamol intoxicated rats

Groups	ALT (U/L)	AST (U/L)	ALP (U/L)	Total Bilirubin (mg/dl)
Control	28.31 ± 2.51	31.27 ± 1.24	194.00 ± 6.60	0.50 ± 0.06
Paracetamol control	20.29 ± 2.21*	187.60 ± 2.83*	617.10 ± 9.51*	3.35 ± 0.07*
Silymarin	33.50 ± 1.61**	36.40 ± 1.05**	270.50 ± 3.14**	0.61 ± 0.03**
100 mg/kg A. americana	42.75 ± 0.99**	45.08 ± 1.04**	297.90 ± 8.30**	1.42 ± 0.05**
200 mg/kg A. americana	38.18 ± 0.75**	42.43 ± 1.01**	283.90 ± 4.11**	0.81 ± 0.05**
400 mg/kg A. americana	36.10 ± 2.38**	38.32 ± 0.77**	273.00 ± 1.01**	0.70 ± 0.05**

Data were expressed as mean ± SEM (n = 6), *P < 0.05 compared with control, **P < 0.05 compared with paracetamol

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