Ellagic acid ameliorates aging-induced renal oxidative damage through upregulating SIRT1 and NRF2

Table 2 Grading of histopathological features in different groups

Histopathological feature	Young	Old	Old + EA
Inflammation	0.0 ± 0.0	3.0 ± 0.4^**	2.2 ± 0.3^#
Necrosis (%)	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
Tubular atrophy (%)	0.0 ± 0.0	14.0 ± 2.4^***	4.0 ± 1.0^##
Tubulointerstitial fibrosis (%)	0.0 ± 0.0	10.4 ± 2.8^**	2.6 ± 0.8^#

Pathological changes were scored as described in Materials and Methods. Data are presented as mean ± SD for n = 7 rats in each group
EA Ellagic acid
^** p<0.01 vs young control
^*** p<0.001 vs young control
^# p<0.05 vs old control
^## p<0.01 vs old control

ISSN: 2662-7671