Table 3 Fold regulation in genes expressed in several pathways after treatment of K562 leukaemia cells with Doxorubicin, Melittin, or Jordanian crude bee venom

Pro-apoptotic genes

 BAX

BCL-2 Associated X-protein

2.26*

-1.32

-1.67

 CASP9

Caspase 9 (initiator caspase)

1.65

-1.62

-1.77

Cell signalling cytokine gene

 TNF

Tumour necrosis factor

2.32*

2.44*

6.18*

Anti-apoptotic gene

 BCL-2

B-cell lymphoma 2

4.66*

1.02

-1.16

Proto-oncogenes

 c- MYC

Recruits histone acetyltransferases

-1.97

-2.14*

-2.80*

 NF-κB RELA

Nuclear factor-kappa-B p65 subunit

2.06*

-1.33

-38.14*

 JUN (AP1)

Forms the AP-1 early response transcription factor

6.01*

3.07*

5.15*

 FOS

Forms a heterodimer with c- JUN

2.83*

-1.06

-1.72

Oncogene

 ABL1 (BCR/ABL)

ABL proto-oncogene 1, non-receptor tyrosine kinase

3.17*

-1.59

2.97*

Cell cycle regulator

 CDK4

Cyclin-dependent kinase 4

-12.81*

-18.26*

-22.38*

 Mitogen-activated protein kinases

 MAPK14 (p38)

Member of the p38 MAPK family

2.23*

-1.72

-2.03*