Table 3 IC50 values of compounds isolated Brucea antidysenterica towards the investigated cell lines
Cell lines | Samples, IC50 (in µM) and D.R.* or S.I.** (in bracket) | ||||||
|---|---|---|---|---|---|---|---|
| Â | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
CCRF-CEM | 19.11 ± 1.56 | 4.28 ± 0.31 | 28.42 ± 1.76 | 31.99 ± 2.16 | 44.22 ± 3.52 | 23.19 ± 1.63 | 20.38 ± 0.94 |
CEM/ADR5000 Degree of resistance* | 32.03 ± 2.05 (1.68) | 3.07 ± 0.18 (0.72) | 73.94 ± 5.32 (2.60) |  > 100 (> 3.13) |  > 100 (> 2.26) |  > 100 (> 4.31) |  > 100 (> 4.91) |
MDA-MB-231-pcDNA | 13.40 ± 0.93 | 4.07 ± 0.37 |  > 100 |  > 100 |  > 100 |  > 100 |  > 100 |
MDA-MB-231-BCRP Degree of resistance | 47.50 ± 2.75 (3.54) | 6.65 ± 0.24 (1.63) |  > 100 |  > 100 |  > 100 |  > 100 |  > 100 |
HCT116 p53+/+ | 23.86 ± 2.32 | 11.44 ± 0.98 |  > 100 |  > 100 | 24.72 ± 2.16 |  > 100 |  > 100 |
HCT116 p53−/− Degree of resistance | 36.43 ± 3.04 (1.53) | 6.74 ± 0.33 (0.59) | 50.48 ± 3.81 (< 0.50) | 32.16 ± 2.37 (< 0.32) | 20.97 ± 1.72 (0.85) |  > 100 |  > 100 |
U87MG | 24.25 ± 1.16 | 9.29 ± 0.73 |  > 100 | 28.29 ± 2.08 | 19.58 ± 1.55 |  > 100 |  > 100 |
U87MG.ΔEGFR Degree of resistance | 36.28 ± 3.01 (1.50) | 5.42 ± 0.44 (0.58) |  > 100 | 28.32 ± 1.66 (1.00) | 21.12 ± 1.49 (1.08) |  > 100 |  > 100 |
HepG2 | 39.94 ± 2.84 | 2.73 ± 0.19 | 85.16 ± 5.70 | 31.17 ± 2.11 | 26.09 ± 1.63 | 15.48 ± 1.06 |  > 100 |
AML12 Selectivity index** |  > 100 (> 2.50) | 51.16 ± 3.20 (18.74) |  > 100 (> 1.17) |  > 100 (> 3.21) |  > 100 (> 3.83) |  > 100 (> 6.46) |  > 100 |