| IC50 of SOR (% change) | |
---|---|---|
HepG2 | MDA-MB-231 | |
Sorafenib alone | 10.83 ± 0.54 (0) | 23.69 ± 0.85 (0) |
SOR + TQ IC10 | 10.21 ± 0.41 (5.7) | 22.24 ± 0.98 (6.1) |
SOR + TQ IC20 | 8.55*** ± 0.24 (21.05) | 19.48* ± 0.57 (17.77) |
SOR + TQ IC30 | 5.05*** ± 0.81 (53.3) | 15.75*** ± 0.75 (33.51) |
SOR + TQ IC40 | 4.54*** ± 0.32 (58.7) | 12.63*** ± 0.35 (46.68) |
SOR + TQ IC50 | 3.91*** ± 0.45 (63.89) | 11.75*** ± 0.47 (50.4) |
SOR + PIP IC10 | 10.52 ± 0.72 (2.86) | 21.35 ± 0.79 (9.87) |
SOR + PIP IC20 | 10.24 ± 0.47 (5.44) | 19.20* ± 0.53 (18.95) |
SOR + PIP IC30 | 7.57** ± 0.82 (30.1) | 14.75*** ± 0.437 (37.73) |
SOR + PIP IC40 | 5.12*** ± 0.22 (52.72) | 10.85*** ± 0.48 (54.2) |
SOR + PIP IC50 | 3.14*** ± 0.18 (71.0) | 10.5*** ± 0.37 (55.67) |
SOR + TQ IC10 + PIP IC10 | 9.34* ± 0.42 (13.7) | 19.54* ± 0.82 (17.51) |
SOR + TQ IC20 + PIP IC20 | 7.88*** ± 0.29 (27.23) | 16.33*** ± 0.57 (31.06) |
SOR + TQ IC30 + PIP IC30 | 4.24*** ± 0.32 (60.84) | 12.47*** ± 0.90 (47.36) |
SOR + TQ IC40 + PIP IC40 | 3.17*** ± 0.40 (70.72) | 10.48*** ± 0.37 (55.76) |
SOR + TQ IC50 + PIP IC50 | 1.54*** ± 0.12 (85.78) | 5.89*** ± 0.65 (75.13) |