Table 1 Prevalence of herb-drug interactions based on demographic and clinical information of cancer patients referred to the outpatient clinics to receive chemotherapy courses (n = 262)

Sex

Male

74

51 (68.9)

58.1 – 78.4

Female

188

158 (84.0)

78.7 – 89.3

Marital status

Single

14

11 (78.6)

57.1 – 100.0

Married

248

198 (79.8)

74.6 – 84.7

Area of resident

Urban

204

164 (80.4)

75 – 85.3

Rural

58

45 (77.6)

65.6 – 87.9

Education level

Under diploma

152

116 (76.3)

69.1 – 82.9

Diploma and more

110

93 (84.5)

77.3 – 90.9

Cancer site

Breast

98

92 (93.9)

88.8 – 98

Gastrointestinal

51

28 (54.9)

41.2 – 68.6

Lymphoma and hematologic tumors

46

37 (80.4)

67.4 – 91.3

Gynecologic

30

26 (86.7)

73.3 – 96.7

Thorax

14

9 (64.3)

42.9 – 85.7

Other sites

23

17 (73.9)

56.5 – 91.3

Clinical stage

I

18

12 (66.7)

44.4 – 88.9

II

42

35 (83.3)

71.4 – 92.9

III

48

39 (81.3)

70.8 – 91.7

IV

37

33 (89.2)

78.4 – 97.3

Unclear

117

90 (76.9)

68.4 – 84.6

Metastatic status

Negative

139

109 (78.4)

71.2 – 84.9

Positive

117

96 (82.1)

75.2 – 88.9

Unclear

6

4 (66.7)

33.3—100

Recurrence status

Negative

210

167 (79.5)

73.8 – 84.8

Positive

45

38 (84.4)

73.3 – 93.3

Unclear

7

4 (57.1)

28.6 – 85.7

Comorbid illness

Negative

124

96 (77.4)

70.2 – 84.7

Positive

138

113 (81.9)

76.1 – 87.7

Nausea and vomiting

Negative

76

56 (73.7)

64.5 – 82.9

Positive

186

153 (82.3)

76.9 – 87.1

Constipation and diarrhea

Negative

93

74 (79.6)

71 – 88.2

Positive

169

135 (79.9)

73.4 – 85.8

Pain

Negative

102

70 (68.6)

59.8 – 77.5

Positive

160

139 (86.9)

81.9 – 91.9

Oral lesions

Negative

134

102 (76.1)

68.7 – 83.6

Positive

128

107 (83.6)

77.3 – 89.8

Skin lesions

Negative

130

100 (76.9)

70 – 84.6

Positive

132

109 (82.6)

76.5 – 88.6