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Table 4 Biochemical profile of male rats treated with the aqueous extract of O. lamiifolium

From: Sub-chronic toxicity of the aqueous leaf extract of Ocimum lamiifolium Hochst. ex Benth on biochemical parameters and histopathology of liver and kidney in rats: in vivo and in- silico toxicity studies

Tests

Group

Group I 200 mg/ kg

Group II 400 mg/ kg

Group III 600 mg/ kg

Group IV Control

ALT (U/L)

47.8 ± 12.3

47.7 ± 4.0

69.0 ± 8.6a

47.4 ± 6.4

AST (U/L)

129.2 ± 10.8

118.4 ± 9.4

184.4 ± 18.1b

137.7 ± 20.5

ALP (U/L)

76.2 ± 1.4

80.0 ± 7.0

106.2 ± 5.4c

78.2 ± 2.0

Urea (mg/dL)

48.6 ± 5.1

44.1 ± 2.5

42.5 ± 7.4

49.7 ± 3.0

Creatinine(mg/dL)

0.30 ± 0.0

0.32 ± 0.0

0.32 ± 0.0

0.35 ± 0.0

Albumin (g/dL)

4.3 ± 0.1

4.4 ± 0.1

4.4 ± 0.1

4.1 ± 0.2

Total protein (g/dL)

5.9 ± 0.1

5.9 ± 0.1

6.1 ± 0.2

6.0 ± 0.1

Total cholesterol (mg/dL)

40.7 ± 2.3

41.5 ± 2.2

42.5 ± 2.5

38.7 ± 1.5

Glucose (mg/dL)

106.8 ± 9.2

96.4 ± 14.8

83.4 ± 10.5a

123.5 ± 11.7

  1. Results are expressed as mean ± SMD. For all p-value was < 0.05, One-Way ANOVA. ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase
  2. a significantly different from the control group (Dunnett test)
  3. b significant difference with all the other groups
  4. c significant difference with groups I and IV
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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