Fig. 3

Effect of combined use of HQS and OS in experiment 3. To assess whether the use of HQS could increase the pharmacodynamic level of OS or reduce the dose of OS, 70 mice were divided into control group (distilled water); model group (distilled water); OS group (OS, 27.5 mg/kg/d); and Co 1 (HQS 165 mg/kg/d with OS 27.5 mg/kg/d), Co 2 (HQS 165 mg/kg/d with OS 14 mg/kg/d), Co 3 (HQS 165 mg/kg/d with OS 7 mg/kg/d), and Co 4 (HQS 82.5 mg/kg/d with OS 14 mg/kg/d) groups (n = 10). Mice were intranasally infected with 15 LD₅₀ of influenza A virus. On day 5 after infection, the lungs of the mice were collected for analyzing lung index (A, n ≥ 9) and lung pathology (B, 100 × , n = 7). Results are represented as mean ± SD, ^*P < 0.05, ^**P < 0.01, compared to the model group