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Table 1 The 50% inhibitory concentrations, 50% cytotoxicity concentration and selectivity index values of the extracts

From: Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice

Type of extract/Control

IC50 (μg/ml) on 3D7

CC50 (μg/ml) on Vero cells

SI

Methanol

1.756

247

140

Aqueous macerate

2.283

1786

781

Methanol + Ethyl acetate

4.209

ND

 

Ethyl acetate

4.728

ND

 

Aqueous macerate+ ethyl acetate)

5.831

ND

 

Aqueous decoction

6.831

ND

 

Chloroform

12.130

ND

 

Methanol+ Hexane

14.560

ND

 

Aqueous macerate + hexane

17.650

ND

 

Hexane

18.470

ND

 

Pyrimethamine (positive control)

0.003

  
  1. IC50 (50% inhibitory concentrations); CC50 (50% cytotoxicity concentration); SI (selectivity index); ND (Not determined)