Fig. 2
Antimalarial activity of DHA and GIE against PbANKA in infected mice. BALB/c mice were infected with 1 × 107 parasitized erythrocytes of PbANKA by IP injection and subsequently administered DHA (0.1, 1, 5, 10, or 20 mg/kg) and GIE (1, 10, 50, 100, or 200 mg/kg) by gavage for four consecutive days. On day 4, a parasitemia (%) was measured and b ED50 values (mg/kg) were calculated. Results are presented as mean ± SEM (n = 5). DHA, dihydroartemisinin; GIE, Gymnema inodorum leaf extract; UN, untreated control. *p < 0.05, **p < 0.01, and ***p < 0.001, compared to untreated control