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Table 5 Effect of P. peruviana L. calyces extract and butanol fraction on serum urea and creatinine levels in Cd-induced nephrotoxicity in rats

From: Nephroprotective effect of Physalis peruviana L. calyx extract and its butanolic fraction against cadmium chloride toxicity in rats and molecular docking of isolated compounds

Groups and doses (mg/kg)

Serum urea (mg/dL)

Serum creatinine (mg/dL)

Control

5.18 ± 0.30

0.57 ± 0.04

CdCl2 3

9.65 ± 0.65 a c

1.32 ± 0.09 a c

AME 500

8.55 ± 0.40 a

1.12 ± 0.07 a c

AME 1000

7.41 ± 0.26 a b

1.01 ± 0.02 a b

Bu.F. 500

7.15 ± 0.30 a b

0.86 ± 0.02 a b

Bu.F. 1000

6.05 ± 0.43 b

0.70 ± 0.03 b

Silymarin 150

6.90 ± 0.30 b

0.84 ± 0.02 a b

  1. Data presented as: Mean ± SE (n = 6)
  2. a Significant from control group at P < 0.05
  3. b Significant from CdCl2 group at P < 0.05
  4. c Significant from standard group at P < 0.05
  5. CdCl2 Cadmium chloride, AME Aqueous Methanolic Extract, Bu.F Butanol Fraction