Table 6 Predicted degradation products of the bioactive compounds
Bioactive compounds | Product | Reaction type | Enzymes |
|---|---|---|---|
N,N-Diethylurea | Ornithine | Hydroxylation of terminal methyl | Cytochrome P450 1A2 |
1,3- Cyclohexanediol | 3- Hydroxycyclohexanone | Dehydrogenation of secondary alcohol | Alcohol dehydrogenase |
6-Methyl-2-heptyne | Cyclooctenone | Hydroxylation of terminal methyl | Cytochrome P450 1A2 |
N- Acetylethylenediamine | NA | NA | NA |
Cyclopropanecarboxamide | N-Glucuronidation of amide | N-Glucuronidation of amide | UDP-glucuronosyltransferase |
N-Acetyl-L-methionine | Thiamet G | Glycine conjugation | Glycine N Acyltransferase |
Succinic acid | Maleic acid | Dehydrogenation of (D)-2-hydroxy acid | Phosphoglucomutase-1 |
Trimethoprim (control) | 3'-Hydroxytrimethoprim; 5-[(2,4-Diaminopyrimidin-5-yl) methyl]-2,3-dimethoxyphenol | Dephosphorylation of 5'-ribonucleotide | Unspecified microbial bile acid: amino acid N-acetyltransferase |