A novel therapeutic effect of mannitol-rich extract from the brown seaweed Sargassum ilicifolium using in vitro and in vivo models

Table 3 WBC and RBC count during the experimental period.

Test	Day	Normal	Control	Treatment I	Treatment II	Treatment III
RBC	0	3.32± 0.18	3.08± 0.11	3.75± 0.11	4.34± 0.25	3.79± 0.11
	5	4.80±0.10	5.25±0.03	5.47± 0.07	3.96± 2.03 ^a†	5.15± 0.48
	10	5.60± 0.02	4.69± 0.38	8.20±0.39	7.99± 0.37 ^a*	7.24± 0.07
	15	5.66± 0.29	7.19± 0.04	7.80±0.14	10.97± 1.40 ^a*	7.63± 0.28
	20	5.89± 0.29	7.23± 0.07	9.21± 1.05	8.16± 0.08	7.44± 0.38
WBC	0	7.95±0.20	7.85±0.55	8.70±0.26	7.82±0.82	6.45±0.26
	5	6.47±0.04	9.87±0.27	7.55±1.07	9.37±0.73	6.90±1.04
	10	6.32±0.79	7.40±0.32	8.87±0.62	6.60±0.14	11.03±2.06
	15	6.97±0.01	10.15±1.12	7.20±0.66	7.87±0.27	8.50±0.03
	20	7.77±0.27	7.30±0.49	7.72±1.54	4.92±0.13	7.62±0.24

Values are expressed as mean ± SEM; Data is compared against a control group. a = denote when compare to the control group, b = denote when compare to the treatment II Group, (*) indicates statistically significant difference and (†) indicates statistically no significant difference from respective group using ANOVA, followed by Tukey comparisons test (P > 0.05). Control: received an equal amount of distilled water, orally, Treatment I: received S. ilicifolium CE (100 mg/Kg BW/day for 14 days, orally), Treatment II: received S. ilicifolium CE (100 mg/kg/BW/day for 21 days, orally), Treatment III: received S. ilicifolium CE without wound (100 mg/kg BW/day for 14 days, orally)

ISSN: 2662-7671