A novel therapeutic effect of mannitol-rich extract from the brown seaweed Sargassum ilicifolium using in vitro and in vivo models

Table 1 Biochemical parameters of rabbit of each test group over a period of 20 days.

Biochemical test	Normal	Control	Treatment I	Treatment II	Treatment III
AST (IU/L)	51.77±9.96	46.86±9.52	45.86±10.66^ab†	42.41±9.31	42.18±8.30^a†
ALT (IU/L)	44.89±4.80	76.66±24.85	60.55±14.16^ab†	39.07±8.22	47.34±11.23^ab†
Creatinine (mg/dl)	1.216±0.06	1.072±0.091	1.34±0.08	1.20±0.064	1.47±0.04

Values are expressed as mean ± SEM; Data is compared against a control group. a = denote when compare to the control group, b = denote when compare to the treatment II Group, (*) indicates statistically significant difference and (†) indicates statistically no significant difference from respective group using ANOVA, followed by Tukey comparisons test (P > 0.05). Control: received an equal amount of distilled water, orally, Treatment I: received S. ilicifolium CE (100 mg/Kg BW/day for 14 days, orally), Treatment II: received S. ilicifolium CE (100 mg/kg/BW/day for 21 days, orally), Treatment III: received S. ilicifolium CE without wound (100 mg/kg BW/day for 14 days, orally)

ISSN: 2662-7671