From: In vitro and in vivo anthelmintic and chemical studies of Cyperus rotundus L. extractsÂ
Drugs | Drug dose μg/ml | Exposure time (h) | LC50μg/ml | ||||
---|---|---|---|---|---|---|---|
1Â h | 4Â h | 24Â h | 48Â h | 72Â h | |||
Parasite control | 25 ± 0.0 | 25 ± 0.0 | 23 ± 0.2 | 22 ± 0.35 | 20.5 ± 0.41 |  | |
DMSO control | 24.5 ± 0.02 | 24 ± 0.1 | 22.5 ± 0.35 | 20.5 ± 0.8 | 20 ± 0.95 |  | |
Albendazole | 400 | 4 ± 0.93** | 0 ± 0** | 0 ± 0** | 0 ± 0** | 0 ± 0** | 71.41 |
200 | 11.5 ± 2.5** | 8 ± 2.8** | 0 ± 0** | 0 ± 0** | 0 ± 0** | ||
100 | 19.5 ± 3.2* | 16 ± 2.65* | 6.5 ± 1.23** | 0 ± 0** | 0 ± 0** | ||
50 | 23.5 ± 1.8 | 20.5 ± 2.3 | 17.5 ± 3.5* | 11.5 ± 3.5* | 9.5 ± 2.5* | ||
25 | 24.5 ± 3.4 | 23 ± 2.5 | 20.5 ± 3.5 | 17.5 ± 3.7 | 15 ± 2.8 | ||
90%MeOH ext | 500 | 19.5 ± 3.2* | 18.5 ± 4.3* | 12 ± 3.5* | 6 ± 1.3** | 0 ± 0** | 156.13 |
250 | 21.5 ± 4.2 | 20 ± 3.2 | 16.5 ± 2.4* | 9.5 ± 2.3** | 2.5 ± 3.5** | ||
125 | 23.5 ± 3.9 | 23 ± 5.2 | 19.5 ± 3.6 | 17 ± 1.5 | 11.5 ± 1.5* | ||
50 | 25 ± 5.4 | 24.5 ± 3.1 | 22.5 ± 2.8 | 19.5 ± 2.9 | 17 ± 2.5 | ||
25 | 25 ± 3.8 | 25 ± 4.2 | 23.5 ± 3.5 | 20.5 ± 3.6 | 20.5 ± 2.3 | ||
EtOAc fr | 500 | 17.5 ± 2.8* | 15 ± 3.4* | 8 ± 2.5** | 3.5 ± 1.2** | 0 ± 0** | 294.67 |
250 | 20.5 ± 3.8 | 18 ± 2.1* | 13.5 ± 3.6* | 7 ± 2.0** | 0 ± 0** | ||
125 | 22.5 ± 2.9 | 22 ± 3.6 | 16.5 ± 2.4* | 13 ± 3.2* | 8.5 ± 2.1** | ||
50 | 23.5 ± 3.7 | 23 ± 2.7 | 21 ± 2.1 | 18.5 ± 2.5 | 16 ± 1.2 | ||
25 | 25 ± 2.8 | 24 ± 4.2 | 23.5 ± 3.5 | 21 ± 3.1 | 20 ± 2.3 | ||
Pet-ether fr | 500 | 12.5 ± 3.9** | 9 ± 3.1** | 3.0 ± 0.9** | 0 ± 0** | 0 ± 0** | 82.09 |
250 | 18.5 ± 2.7* | 15 ± 4.1* | 9.5 ± 2.5** | 2.5 ± 0.9** | 0 ± 0** | ||
125 | 22.5 ± 3.2 | 18 ± 3.1* | 14.5 ± 1.6* | 8.5 ± 1.6** | 3 ± 1.2** | ||
50 | 24.5 ± 4.2 | 23 ± 2.5 | 18.5 ± 3.2 | 13.5 ± 3.2 | 12.5 ± 2.3* | ||
25 | 25 ± 1.9 | 23.5 ± 3.5 | 22.5 ± 2.1 | 20.5 ± 2.5 | 19.5 ± 3.1 | ||
n-BuOH fr | 500 | 9.5 ± 3.5** | 6 ± 3.6** | 0 ± 0** | 0 ± 0** | 0 ± 0** | 73.16 |
250 | 14.5 ± 4.3** | 10 ± 2.4** | 2.5 ± .2** | 0 ± 0** | 0 ± 0** | ||
125 | 19.5 ± 2.3* | 16 ± 1.8* | 10.5 ± 3.2** | 0 ± 0** | 0 ± 0** | ||
50 | 23 ± 4.3 | 22.5 ± 6.8 | 18 ± 2.5 | 14 ± 3.2 | 11 ± 3.2* | ||
25 | 24 ± 2.9 | 23.5 ± 3.3 | 21.5 ± 1.9 | 18.5 ± 2.1 | 17.5 ± 2.4 |