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Table 4 IC50 values of the 12 components in the L-02 and AML-12 cell lines

From: Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns

Component

50% inhibitory concentration (IC50) value

L-02 cell line

AML-12 cell line

Parthenolide

(11.47 ± 1.03) μM

NA

Triptolide

(28.06 ± 1.02) nM

(27.77 ± 1.09) nM

Triptonide

(75.79 ± 8.88) nM

(91.49 ± 3.10) nM

Triptophenolide

NA

NA

Triptobenzene H

NA

NA

Hypodiolide

NA

NA

Celastrol

(6.74 ± 1.18) μM

(4.62 ± 1.30) μM

Demethylzeylasteral

(2.02 ± 1.03) μM

(4.03 ± 1.78) μM

Wilforlide A

NA

NA

Triptotriterpenic acid A

NA

(16.09 ± 1.32) μM

Regelidine

NA

NA

Wilforine

NA

NA

  1. N = 6
  2. NA Not Available; the highest concentration tested was 25 μM; three experimental replicates in all panels