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Table 4 In vitro antimalarial activity and cytotoxicity of ethanolic and aqueous extracts of Prabchompoothaweep remedy ingredients

From: Antimalarial efficacy and toxicological assessment of medicinal plant ingredients of Prabchompoothaweep remedy as a candidate for antimalarial drug development

No

Plant species

Part used

Ethanolic extract

Aqueous extract

IC50 (μg/ml)

CC50 (μg/ml)

SI

IC50 (μg/ml)

CC50 (μg/ml)

SI

1

A. ebracteatus

Whole plant

18.94 ± 4.82

96.43 ± 14.32

5.09

>  200

114.00 ± 14.10

<  0.57

2

P. nigrum

Fruit

4.38 ± 2.58

194.30 ± 61.00

44.36

>  200

185.40 ± 0.40

<  0.93

3

L. sibiricus

Leaf

13.65 ± 0.35

20.51 ± 0.15

1.50

>  200

185.70 ± 2.20

<  0.93

4

K. hospital

Whole plant

14.39 ± 12.99

111.00 ± 7.95

7.71

77.36 ± 6.34

>  200

2.81

5

S. aromaticum

Flower

7.15 ± 6.79

>  200

>  27.97

1.96 ± 0.88

134.70 ± 14.09

68.72

6

A. paeoniifolius

Whole plant

152.93 ± 0.68

140.50 ± 1.42

0.92

>  200

>  200

>  1.00

7

T. arjuna

Fruit

4.72 ± 2.28

>  200

>  42.37

4.05 ± 0.54

>  200

>  54.22

8

T. chebula

Fruit

5.05 ± 1.86

199.30 ± 40.45

39.47

4.53 ± 0.82

>  200

>  106.78

9

P. indica

Roots

8.43 ± 5.27

>  200

>  23.72

> 200

>  200

>  1.00

10

Z. officinale

Rhizomes

3.42 ± 1.68

105.10 ± 13.85

30.73

56.96 ± 0.65

136.80 ± 8.90

2.40

11

L. sativum

Fruit

68.80 ± 3.54

57.53 ± 1.365

0.84

>  200

145.40 ± 15.45

<  0.73

12

A. graveolens

Fruit

27.28 ± 0.94

49.51 ± 1.54

1.81

>  200

>  200

>  1.00

13

F. vulgare

Fruit

16.04 ± 1.53

31.50 ± 1.40

1.96

157.77 ± 1.00

96.23 ± 34.55

0.61

14

N. sativa

Seed

57.32 ± 1.40

88.46 ± 23.96

1.54

> 200

>  200

< 6.55

15

A. dahurica

Root

28.10 ± 0.82

69.92 ± 8.77

2.49

146.70 ± 1.41

>  200

>  1.36

16

A. lancea

Root

7.37 ± 7.72

29.54 ± 0.63

4.01

> 200

167.30 ± 7.05

<  0.84

17

A. elliptica

Fruit

7.08 ± 0.72

113.30 ± 0.45

16.00

126.98 ± 5.12

>  200

>  1.58

18

E. acoroides

Fruit

>  200

93.74 ± 8.66

< 0.47

> 200

146.30 ± 7.90

<  0.73

19

P. chaba

Flower

2.06 ± 0.62

198.60 ± 7.9

96.41

> 200

>  200

< 1.44

20

M. fragrans

Seed

13.68 ± 0.54

>  200

>  14.62

> 200

77.09 ± 4.43

<  0.39

21

M. fragrans

Aril

5.96 ± 1.73

38.30 ± 7.71

6.43

> 200

113.80 ± 17.71

<  0.57

22

A. testaceum

Fruit

13.76 ± 0.59

132.90 ± 12.75

9.66

144.77 ± 0.50

>  200

>  1.38

23

C. camphora

Leaf

59.65 ± 1.02

>  200

>  3.35

62.21 ± 2.01

>  200

>  3.21

24

Remedy

 

14.13 ± 0.42

121.60 ± 17.9

8.61

137.10 ± 2.75

161.8 ± 72.12

1.18

 

Artesunate

IC50 = 1.25 ± 0.52 ng/ml

 

Doxorubicin

CC50 = 1.60 ± 0.23 μg/ml

  1. Data are presented as the mean ± standard error of the mean (SEM)
  2. IC50: 50% inhibition concentration; CC50: 50% cytotoxic concentration