Table 5 Differential proteins and metabolites enriched by the common metabolic pathways in GSK/OVX and OVX/SHAM. * represents a protein or metabolite with differential expression trends between GSK/OP and OP/SHAM
No. | Metabolic pathway | Enriched protein | Enriched metabolites | ||||||
|---|---|---|---|---|---|---|---|---|---|
GSK/OP | OP/SHAM | GSK/OP | OP/SHAM | ||||||
1 | Purine metabolism | *Cant1 | ↓ | *Cant1 | ↑ | L-Glutamine | ↓ | Xanthosine | ↓ |
Prps | ↓ | Enpp3 | ↑ | Inosine | ↑ | Glycine | ↑ | ||
|  |  |  |  | Adenosine | ↓ |  |  | ||
2 | Tyrosine metabolism | *Gstz1 | ↓ | *Gstz1 | ↑ | *Tyramine | ↓ | Maleic acid | ↑ |
*Aldh3b1 | ↓ | *Aldh3b1 | ↑ |  |  | *Tyramine | ↑ | ||
3 | Pyrimidine metabolism | *Cant1 | ↓ | *Cant1 | ↑ | Dihydrouracil | ↓ | 2'-Deoxyuridine | ↓ |
*Thymidine | ↑ | *Thymine | ↓ | ||||||
L-Glutamine | ↓ | *Thymidine | ↓ | ||||||
*Thymine | ↑ | *Deoxycytidine | ↓ | ||||||
*Deoxycytidine | ↑ | *Cytosine | ↑ | ||||||
*Cytosine | ↓ |  |  | ||||||
4 | Histidine metabolism | *Aldh3b1 | ↓ | *Aldh3b1 | ↑ | *L-Aspartate | ↓ | L-Glutamate | ↑ |
*Ergothioneine | ↑ | *L-Aspartate | ↑ | ||||||
*L-Histidine | ↑ | *L-Histidine | ↓ | ||||||
*L-Anserine | ↑ | *L-Anserine | ↓ | ||||||
3-Methylhistidine | ↑ | *Ergothioneine | ↓ | ||||||
5 | beta-Alanine metabolism | *Aldh3b1 | ↓ | *Aldh3b1 | ↑ | Dihydrouracil | ↓ | *L-Aspartate | ↑ |
*L-Aspartate | ↓ | *Pantothenate | ↑ | ||||||
*L-Histidine | ↑ | *Histidine | ↓ | ||||||
*Pantothenate | ↑ | *L-Anserine | ↓ | ||||||
*L-Anserine | ↑ |  |  | ||||||
6 | Pathways in cancer | Calml3 *Bid | ↓ ↓ | Fn1 Kng2 *Bid Cdk4 | ↑ ↑ ↑ ↑ | 1-Stearoyl-2-arachidonoyl-sn-glycerol | ↑ | L-Malic acid | ↑ |
7 | Platelet activation | Src | ↓ | Rlc-a | ↑ | *Arachidonic Acid (peroxide free) | ↑ | *Arachidonic Acid (peroxide free) | ↓ |
Fgb | ↓ | ||||||||
Col1a1 | ↓ | 1-Stearoyl-2-arachidonoyl-sn-glycero | ↑ | ||||||
Col1a2 | ↓ | Prostaglandin I2 | ↑ | ||||||
8 | Inflammatory mediator regulation of TRP channels | Calml3 | ↓ | Kng2 | ↓ | *Arachidonic Acid (peroxide free) | ↑ | *Arachidonic Acid (peroxide free) | ↓ |
Src | ↓ |  |  | 1-Stearoyl-2-arachidonoyl-sn-glycerol | ↑ | ||||
9 | Phenylalanine metabolism | *Aldh3b1 | ↓ | *Aldh3b1 | ↑ | Hippuric acid | — | *Benzoic acid | ↓ |
*Benzoic acid | ↑ | *DL-Phenylalanine | ↑ | ||||||
*DL-Phenylalanine | ↓ |  |  | ||||||
10 | Glutamatergic synapse | *Slc1a3 | ↓ | *Slc1a3 | ↑ | L-Glutamine | ↓ | L-Glutamate | ↑ |
1-Stearoyl-2-arachidonoyl-sn-glycerol | ↑ |  |  | ||||||
11 | Gap junction | Src | ↓ | Tubb2a | ↓ | 1-Stearoyl-2-arachidonoyl-sn-glycerol | ↑ | L-Glutamate | ↑ |