Randomized double-blind placebo-controlled multicenter trial for the effects of a polyherbal remedy, Yokukansan (YiganSan), in smokers with depressive tendencies

Table 4 Patient data before and after 12 weeks of smoking cessation intervention

	Placebo group (n = 53)		p value ^a Baseline vs. 12-week	Yokukansan group (n = 55)		p value ^a Baseline vs. 12-week
	Baseline	12-week	p value ^a Baseline vs. 12-week	Baseline	12-week	p value ^a Baseline vs. 12-week
BMI (kg/m²)	22.7 (3.4)	23.1 (3.6)	*.009*	23.5 (3.7)	24.0 (3.8)	< *.001*
SBP (mm Hg)	138 (26)	137 (21)	.968	131 (18)	137 (18)	*.018*
DBP (mm Hg)	78 (19)	77 (15)	.454	76 (13)	78 (13)	.313
Respiratory CO (ppm)	18.9 (10.8)	4.8 (3.9)	< *.001*	18.4 (10.5)	4.9 (5.6)	< *.001*
SDS test score	45.6 (4.2)	42.1 (8.3)	*.004*	46.8 (5.2)	42.3 (7.4)	< *.001*
POMS score
Tension-Anxiety(T-A)	5.4 (3.5)	3.8 (3.4)	*.001*	5.3 (3.7)	3.7 (3.5)	*.013*
Depression-Dejection(D)	3.4 (3.2)	3.3 (3.0)	.768	4.4 (4.2)	2.6 (3.2)	*.003*
Anger-Hostility (A-H)	3.8 (3.3)	3.7 (3.8)	.890	4.4 (4.5)	3.1 (4.3)	.062
Vitality(V)	5.3 (3.7)	6.5 (4.3)	.053	5.3 (4.2)	6.5 (5.0)	.123
Fatigue(F)	5.7 (4.5)	5.2 (4.6)	.452	6.2 (4.8)	4.1 (4.0)	*.002*
Confusion(C)	5.7 (3.0)	5.1 (3.0)	.174	5.8 (3.1)	4.8 (2.5)	*.015*

Data are presented as the mean (standard deviation)
BMI Body mass index, SBP Systolic blood pressures, DBP Diastolic blood pressures, CO Carbon monoxide, SDS test score, self-rating depression scale test score, POMS Profile of mood states
^a paired t test between baseline and 12-week

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