Exploring the pharmacological mechanism of Shengjing capsule on male infertility by a network pharmacology approach

Wang, Ming; Wang, Qi; Jiang, Hui; Du, Yongqiang; Zhang, Xiansheng

doi:10.1186/s12906-022-03774-z

BMC Complementary Medicine and Therapies

Table 1 The final selected compounds in Shengjing capsule for analysis

From: Exploring the pharmacological mechanism of Shengjing capsule on male infertility by a network pharmacology approach

ID	COMPOUND	HERBS	OB	DL	ID	COMPOUND	HERBS	OB	DL
MOL000006	luteolin	EH	36.16	0.25	MOL004427	Icariside A7	EH	31.91	0.86
MOL000098	quercetin	LF AC RLF EH RF CS	46.43	0.28	MOL004564	Kaempferid	AC	73.41	0.27
MOL000184	NSC63551	AC CS	39.25	0.76	MOL004941	(2R)-7-hydroxy-2-(4-hydroxyphenyl)chroman-4-one	PR	71.12	0.18
MOL000354	isorhamnetin	CS	49.6	0.31	MOL005030	gondoic acid	RLF	30.7	0.2
MOL000358	beta-sitosterol	CO LF AC RLF RF PR CR CS PG	36.91	0.75	MOL005043	campest-5-en-3beta-ol	CS	37.58	0.71
MOL000359	sitosterol	EH RF PR	36.91	0.75	MOL005308	Aposiopolamine	PG	66.65	0.22
MOL000392	formononetin	AC	69.67	0.21	MOL005317	Deoxyharringtonine	PG	39.27	0.81
MOL000417	Calycosin	AC	47.75	0.24	MOL005318	Dianthramine	PG	40.45	0.2
MOL000422	kaempferol	AC RLF EH RF CS PG	41.88	0.24	MOL005320	arachidonate	PG	45.57	0.2
MOL000448	isobavachin	FP	54.44	0.32	MOL005321	Frutinone A	PG	65.9	0.34
MOL000449	stigmasterol	LF CR PG FP	43.83	0.76	MOL005344	ginsenoside rh2	PG	36.32	0.56
MOL000546	diosgenin	PR	80.88	0.81	MOL005348	Ginsenoside-Rh4_qt	PG	31.11	0.78
MOL000622	Magnograndiolide	EH	63.71	0.19	MOL005356	Girinimbin	PG	61.22	0.31
MOL000787	Fumarine	PG	59.26	0.83	MOL005376	Panaxadiol	PG	33.09	0.79
MOL000953	CLR	CO LF CS	37.87	0.68	MOL005384	suchilactone	PG	57.52	0.56
MOL001002	ellagic acid	RF	43.06	0.43	MOL005399	alexandrin_qt	PG	36.91	0.75
MOL001323	Sitosterol alpha1	LF	43.28	0.78	MOL005406	Atropine	LF	42.16	0.19
MOL001439	arachidonic acid	CO	45.57	0.2	MOL005438	campesterol	LF	37.58	0.71
MOL001494	Mandenol	LF RLF	42	0.19	MOL005440	Isofucosterol	CS	43.78	0.76
MOL001495	Ethyl linolenate	LF	46.1	0.2	MOL005944	matrine	CS	63.77	0.25
MOL001510	24-epicampesterol	EH	37.58	0.71	MOL006209	cyanin	LF	47.42	0.76
MOL001558	sesamin	CS	56.55	0.83	MOL006331	4',5-Dihydroxyflavone	PR	48.55	0.19
MOL001607	ZINC03982454	CR	36.91	0.76	MOL007449	24-methylidenelophenol	LF	44.19	0.75
MOL001645	Linoleyl acetate	CO EH	42.1	0.2	MOL008173	daucosterol_qt	LF	36.91	0.75
MOL001771	poriferast-5-en-3beta-ol	EH	36.91	0.75	MOL008400	glycitein	LF	50.48	0.24
MOL001792	DFV	EH PR	32.76	0.18	MOL008628	4'-Methyl-N-methylcoclaurine	RLF	53.43	0.26
MOL001941	Ammidin	RF	34.55	0.22	MOL009278	Laricitrin	AC	35.38	0.34
MOL001979	LAN	LF	42.12	0.75	MOL009289	Calycosin-7-O-beta-D-glucopyranoside	AC	41.6	0.81
MOL002714	baicalein	PR	33.52	0.21	MOL009604	14b-pregnane	LF	34.78	0.34
MOL002879	Diop	PG	43.59	0.39	MOL009617	24-ethylcholest-22-enol	LF	37.09	0.75
MOL002959	3'-Methoxydaidzein	PR	48.57	0.24	MOL009618	24-ethylcholesta-5,22-dienol	LF	43.83	0.76
MOL003044	Chryseriol	EH	35.85	0.27	MOL009620	24-methyl-31-norlanost-9(11)-enol	LF	38	0.75
MOL003542	8-Isopentenyl-kaempferol	EH	38.04	0.39	MOL009621	24-methylenelanost-8-enol	LF	42.37	0.77
MOL003578	Cycloartenol	LF CR	38.69	0.78	MOL009622	Fucosterol	LF	43.78	0.76
MOL003648	Inermin	PG	65.83	0.54	MOL009634	31-norlanosterol	LF	42.2	0.73
MOL004114	3,2',4',6'-Tetrahydroxy-4,3'-dimethoxy chalcone	CR	52.69	0.28	MOL009635	4,24-methyllophenol	LF	37.83	0.75
MOL004125	Curculigoside B_qt	CR	83.36	0.19	MOL009639	Lophenol	LF	38.13	0.71
MOL004367	olivil	EH	62.23	0.41	MOL009640	4alpha,14alpha,24-trimethylcholesta-8,24-dienol	LF	38.91	0.76
MOL004373	Anhydroicaritin	EH	45.41	0.44	MOL009641	4alpha,24-dimethylcholesta-7,24-dienol	LF	42.65	0.75
MOL004380	C-Homoerythrinan, 1,6-didehydro-3,15,16-trimethoxy-, (3.beta.)-	EH	39.14	0.49	MOL009642	4alpha-methyl-24-ethylcholesta-7,24-dienol	LF	42.3	0.78
MOL004382	Yinyanghuo A	EH	56.96	0.77	MOL009644	6-Fluoroindole-7-Dehydrocholesterol	LF	43.73	0.72
MOL004384	Yinyanghuo C	EH	45.67	0.5	MOL009646	7-O-Methylluteolin-6-C-beta-glucoside_qt	LF	40.77	0.3
MOL004386	Yinyanghuo E	EH	51.63	0.55	MOL009656	(E,E)-1-ethyl octadeca-3,13-dienoate	LF	42	0.19
MOL004388	6-hydroxy-11,12-dimethoxy-2,2-dimethyl-1,8-dioxo-2,3,4,8-tetrahydro-1H-isochromeno[3,4-h]isoquinolin-2-ium	EH	60.64	0.66	MOL009665	Physcion-8-O-beta-D-gentiobioside	LF	43.9	0.62
MOL004391	8-(3-methylbut-2-enyl)-2-phenyl-chromone	EH	48.54	0.25	MOL009677	lanost-8-en-3beta-ol	LF	34.23	0.74
MOL004394	Anhydroicaritin-3-O-alpha-L-rhamnoside	EH	41.58	0.61	MOL009678	lanost-8-enol	LF	34.23	0.74
MOL004396	1,2-bis(4-hydroxy-3-methoxyphenyl)propan-1,3-diol	EH	52.31	0.22	MOL009681	Obtusifoliol	LF	42.55	0.76
MOL004425	Icariin	EH	41.58	0.61	MOL009763	( +)-Syringaresinol-O-beta-D-glucoside	PR	43.35	0.77
						estrone	CCP	53.56	0.32

Note: AC, CCP, CO, CR, CS, EH, FP, LF, PG, PR, RF, and RLF in the HERBS column represent Astragali Cpmplanatisemen, Cornu Cervi Pantotrichum, Corayceps, Curculiginis Rhizome, Cuscutae Semen, Epimrdii Herba, Fructus Psoraleae, Lycii Fructus, Panax ginseng, Polygonati Rhizoma, Rubi Fructus, and Rosae Laevigatae Fructus, respectively. OB oral bioavailability, DL drug-likeness

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ISSN: 2662-7671

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