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Table 2 Potential central genes of Angelicae Pubescentis Radix against rheumatoid arthritis (RA)

From: Computation and molecular pharmacology to trace the anti-rheumatoid activity of Angelicae Pubescentis Radix

Gene

Full name

CHRM1

Muscarinic acetylcholine receptor M1

PTGS2

Prostaglandin G/H synthase 2

GABRA1

Gamma-aminobutyric acid receptor subunit alpha-1

DPP4

Dipeptidyl peptidase IV

PIK3CG

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform

PRKACA

mRNA of PKA Catalytic Subunit C-alpha

MAOB

Monoamine oxidase [flavin-containing] B

PAQR6

Progesterone receptor

NCOA1

Nuclear receptor coactivator 2

PTGS1

Prostaglandin G/H synthase 1

VEGFA

Vascular endothelial growth factor A

HSP90

Heat shock protein 90

JUN

Transcription factor Jun

KCNC2

Potassium voltage-gated channel subfamily H member 2

BCL2L1

Bcl-2-like protein 1

DRD1

Dopamine D1 receptor

CHRM3

Muscarinic acetylcholine receptor M3

SCN5A

Sodium channel protein type 5 subunit alpha

GABRA2

Gamma-aminobutyric-acid receptor alpha-2 subunit

CHRM4

Muscarinic acetylcholine receptor M4

PDE3A

CGMP-inhibited 3′,5′-cyclic phosphodiesterase

HTR2A

5-hydroxytryptamine 2A receptor

GABRA5

Gamma-aminobutyric-acid receptor alpha-5 subunit

ADRA1A

Alpha-1A adrenergic receptor

GABRA3

Gamma-aminobutyric-acid receptor alpha-3 subunit

CHRM2

Muscarinic acetylcholine receptor M2

ADRA1B

Alpha-1B adrenergic receptor

ADRB2

Beta-2 adrenergic receptor

CHRNA2

Neuronal acetylcholine receptor subunit alpha-2

SERT

Sodium-dependent serotonin transporter

OPRM1

Mu-type opioid receptor

CHRNA7

Neuronal acetylcholine receptor protein, alpha-7 chain

CAMC

Cytochrome P450-cam

BCL2

Apoptosis regulator Bcl-2

BAX

Apoptosis regulator BAX

CASP9

Caspase-9

NAPA

Transcription factor AP-1

CASP3

Caspase-3

CASP8

Caspase-8

ATP1A1

Protein kinase C alpha type

TGFB1

Transforming growth factor beta-1

PON2

Serum paraoxonase/arylesterase 1

MAP 4

Microtubule-associated protein 2

NOS3

Nitric oxide synthase, endothelial

ADRA2A

Alpha-2A adrenergic receptor

SLC6A2

Sodium-dependent noradrenaline transporter

SLC6A3

Sodium-dependent dopamine transporter

LTA4H

Leukotriene A-4 hydrolase

MAOA

Amine oxidase [flavin-containing] A

CTRB1

Chymotrypsinogen B

ADRA2B

Alpha-2B adrenergic receptor

PLAU

Urokinase-type plasminogen activator

F2

Prothrombin

F9

Coagulation factor Xa

TOP2

DNA topoisomerase II

PTPN22

mRNA of Protein-tyrosine phosphatase, non-receptor type 1

RXRA

Retinoic acid receptor RXR-alpha

ESRRG

Estrogen receptor

PIM1

Proto-oncogene serine/threonine-protein kinase Pim-1

ACHE

Acetylcholinesterase