Cinnamomum verum J. Presl. Bark essential oil: in vitro investigation of anti-cholinesterase, anti-BACE1, and neuroprotective activity

Table 1 IC₅₀ values (μg/mL) of different plants EOs toward AChE and BChE

Entry	Plants	anti-AChE activity^a	anti-BChE activity^a,b
1	C. verum	453.7±2.9	184.7±1.1
2	M. communis	405.1±3.9	431.5±34.8****
3	R. graveolens	> 500	333.1±23.6***
4	A. graveolen	> 500	335.7±7.9***
5	M. fragrans	> 500	> 500
6	C. sativus	> 500	> 500
7	Cinnamaldehyde	> 100^c	> 100^c
8	Donepezil	0.020 ± 0.002	1.50 ± 0.27

^a IC₅₀ values were presented as the mean ± SD of three independent experiments
^b Mean comparison of each EO was compared with the value obtained from C. verum through one-way ANOVA test followed by Tukey post-hoc multiple comparisons (****p < 0.0001 and ***p < 0.001)
^c μM

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