Table 1 Absorbed compounds in serum after the oral administration of Zishen Yutai pills in POF mice

M1

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-[3-[4-(4-morpholinylsulfonyl)phenyl]-1-phenyl-1H-pyrazol-4-yl]-, 3,5-bis(2-methylpropyl) ester

[M+H]+

95.91

677.3005

C₃₆H₄₄N₄O₇S

M2

Trichosanic acid

[M+H]+

90.55

279.2323

C₁₈H₃₀O₂

M3

linolenic acid

[M+H]+

90.55

279.2323

C₁₈H₃₀O₂

M4

Tetradecyl (βS)-β-hydroxy-N-(phenylacetyl)-D-phenylalaninate

[M+H]+

86.52

496.3404

C₃₁H₄₅NO₄

M5

Vernolic acid

[M+H]+

80.74

297.2426

C₁₈H₃₂O₃

M6

cholic acid

[M+NH4]+

74.45

426.322

C₂₄H₄₀O₅

M7

3-(2-Furylmethyl)-10-methyl-2-(3-nitrophenyl)pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione

[M+Na]+

74.16

451.1004

C₂₃H₁₆N₄O₅

M8

1-[(2R,4aS,4bS,6aS,6bS,9aR,10aS,10bR,12aS)-2-Hydroxy-4a,6a,8,8-tetramethylhexadecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]ethanone

[M+H]+

67.63

391.2838

C₂₄H₃₈O₄

M9

Ethyl N-[(13E,15R)-15-hydroxy-1,9-dioxoprost-13-en-1-yl]glycinate

[M+H]+

66.69

424.3053

C₂₄H₄₁NO₅

M10

(3α,9ξ,14ξ,16α)-17-Hydroxy-16-methyl-20-oxopregn-5-en-3-yl acetate

[M+H]+

66.69

389.268

C₂₄H₃₆O₄

M11

(3β,5α)-16-Methyl-20-oxopregn-16-en-3-yl acetate

[M+H]+

64.75

373.2731

C₂₄H₃₆O₃

M12

Corticosterone

[M+H]+

52.49

347.221

C₂₁H₃₀O₄

M13

Cortisol

[M+H]+

48.43

363.2163

C₂₁H₃₀O₅

M14

2-[[(3α,5β)-3-Hydroxy-7,24-dioxocholan-24-yl]amino]ethanesulfonic acid

[M+H]+

47.04

498.2884

C₂₆H₄₃NO₆S

M15

Taurocholic acid

[M+H]+

45.73

516.2987

C₂₆H₄₅NO₇S

M16

Benzophenone

[M+H]+

16.37

183.0804

C₁₃H₁₀O

M17

L-Pyroglutmaic acid

[M+H]+

1.46

130.0498

C₅H₇NO₃

M18

Isoleucine

[M+H]+

1.04

132.1017

C₆H₁₃NO₂

M19

Betaine

[M+H]+

1.03

118.0863

C₅H₁₁NO₂