From: Sub-chronic oral toxicity screening of quercetin in mice
Time-line | 1-month | 2-month | 3-month | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CBC counts | AIN76A | AIN76A-Quer Low (62 mg/kg) | AIN76A-Quer Med (125 mg/kg) | AIN76A-Quer High (250 mg/kg) | AIN76A | AIN76A-Quer Low (62 mg/kg) | AIN76A-Quer Med (125 mg/kg) | AIN76A-Quer High (250 mg/kg) | AIN76A | AIN76A-Quer Low (62 mg/kg) | AIN76A-Quer Med (125 mg/kg) | AIN76A-Quer High (250 mg/kg) |
RBC (10^12/l) | 10.2 ± 0.2 | 9.0 ± 1.0 | 8.7 ± 0.8 | 8.9 ± 0.4 | 9.3 ± 0.4 | 9.6 ± 0.2 | 9.7 ± 0.1 | 9.3 ± 0.2 | 10.5 ± 0.5 | 10.1 ± 0.5 | 9.99 ± 0.3 | 8.40 ± 0.9 |
HGB (g/dl) | 17.5 ± 0.3 | 15.6 ± 1.7 | 14.7 ± 1.4 | 15.5 ± 2.4 | 16.2 ± 0.6 | 16.4 ± 0.3 | 16.3 ± 0.3 | 16.1 ± 0.5 | 18.2 ± 1.1 | 17.3 ± 0.9 | 17.1 ± 0.5 | 15.7 ± 0.7 |
HCT (%) | 38.2 ± 1.7 | 35.6 ± 3.4 | 38.2 ± 0.7 | 36.8 ± 0.4 | 37.0 ± 1.4 | 38.4 ± 0.6 | 38.4 ± 0.4 | 37.4 ± 0.8 | 42.3 ± 2.4 | 40.8 ± 1.2 | 40.3 ± 1 | 37.1 ± 1.6 |
MCV (fl) | 40.0 ± 0.1 | 40.1 ± 0.1 | 40.0 ± 0.1 | 40.4 ± 0.2 | 39.8 ± 0.1 | 40.1 ± 0.1 | 39.8 ± 0.2 | 40.2 ± 0.1 | 40.2 ± 0.2 | 40.3 ± 2 | 40.3 ± 0.2 | 40.2 ± 0.1 |
MCH (pg) | 17.2 ± 0.2 | 17.2 ± 0.3 | 16.9 ± 0.3 | 17.3 ± 0.2 | 17.4 ± 0.1 | 17.1 ± 0.1 | 16.9 ± 0.1 | 17.2 ± 0.2 | 17.4 ± 0.3 | 17.0 ± 0.2 | 17.1 ± 0.1 | 17.0 ± 0.1 |
MCHC (g/dl) | 43.1 ± 0.4 | 42.8 ± 0.7 | 42.2 ± 0.6 | 42.8 ± 0.5 | 43.7 ± 0.2 | 42.8 ± 0.3 | 42.5 ± 0.4 | 42.9 ± 0.6 | 43.1 ± 0.8 | 42.4 ± 0.5 | 42.5 ± 0.3 | 42.3 ± 0.2 |
PLT (10^9/l) | 200 ± 21 | 252 ± 51 | 210 ± 38 | 331 ± 62 | 136 ± 23 | 250 ± 45 | 310 ± 58 | 330 ± 74 | 156 ± 24 | 116 ± 29 | 133 ± 44 | 91 ± 31 |
WBC (10^9/l) | 11.1 ± 0.5 | 7.7 ± 1.1 | 8.8 ± 1.1 | 10.4 ± 2.1 | 11.1 ± 0.9 | 9.1 ± 1.2 | 7.9 ± 1.6 | 6.9 ± 0.8 | 9.3 ± 1.6 | 9.0 ± 1.0 | 9.9 ± 1.2 | 8.3 ± 1.3 |
LYM (10^9/l) | 7.6 ± 0.4 | 5.0 ± 0.7 | 6.3 ± 0.7 | 7.2 ± 1.3 | 8.0 ± 0.7 | 6.9 ± 0.8 | 5.6 ± 1.1 | 5.1 ± 0.7 | 6.1 ± 1.0 | 5.4 ± 0.4 | 6.7 ± 0.9 | 5.0 ± 0.8 |
MON (10^9/l) | 0.4 ± 0.2 | 0.4 ± 0.1 | O.4 ± 0.1 | 0.2 ± 0.1 | 0.5 ± 0.2 | 0.5 ± 0.2 | 0.4 ± 0.2 | 0.2 ± 0.1 | 0.5 ± 0.1 | 0.3 ± 0.1 | 0.6 ± 0.1 | 0.2 ± 0.1 |
NEU (10^9/l) | 3.1 ± 0.1 | 2.3 ± 0.4 | 2.1 ± 0.4 | 2.9 ± 0.6 | 2.6 ± 0.3 | 1.8 ± 0.3 | 1.9 ± 0.4 | 1.6 ± 0.2 | 2.7 ± 0.5 | 2.7 ± 0.5 | 3.0 ± 0.3 | 2.5 ± 0.3 |