Table 2 ADMET information of (S)-Stylopine, Isobrucine and Stigmasterol
Compounds | (S)-Stylopine | Isobrucine | Stigmasterol | Co-crystal lig1 | Co-crystal lig2 |
|---|---|---|---|---|---|
PubChem CID | 440,583 | 3,081,763 | 5,280,794 | NA | NA |
GI absorption | High | High | Low | Low | Low |
BBB permeant | Yes | Yes | No | No | No |
CYP2D6 inhibitor | Yes | Yes | No | No | No |
CYP3A4 inhibitor | Yes | No | No | Yes | No |
CYP1A2 inhibitor | Yes | No | No | No | No |
CYP2C19 inhibitor | Yes | No | No | No | No |