Reproductive and endocrine effects of artemisinin, piperaquine, and artemisinin-piperaquine combination in rats

Table 2 The organ weights of the female rats after administered with ATQ, PQ, or ART at three doses for 14 days (n = 10)

Group	Kidney (g)		Adrenal gland (g)		Ovary (g)		Uterus (g)
Group	Left	Right	Left	Right	Left	Right	Uterus (g)
Control	0.898 ± 0.075	0.908 ± 0.054	0.052 ± 0.006	0.049 ± 0.005	0.067 ± 0.011	0.074 ± 0.011	0.503 ± 0.218
ART low-dose	0.860 ± 0.059	0.883 ± 0.066	0.051 ± 0.006	0.049 ± 0.004	0.072 ± 0.026	0.065 ± 0.015	0.488 ± 0.172
ART mid-dose	0.887 ± 0.085	0.940 ± 0.095	0.052 ± 0.006	0.046 ± 0.004	0.065 ± 0.012	0.065 ± 0.017	0.468 ± 0.180
ART high-dose	0.851 ± 0.064	0.877 ± 0.068	0.056 ± 0.012	0.052 ± 0.017	0.068 ± 0.017	0.070 ± 0.014	0.607 ± 0.200
PQ low-dose	1.062 ± 0.054^*	1.094 ± 0.037^*	0.068 ± 0.011^*	0.059 ± 0.004^*	0.068 ± 0.016	0.069 ± 0.010	0.461 ± 0.145
PQ mid-dose	1.064 ± 0.099^*	1.114 ± 0.082^*	0.068 ± 0.009^*	0.062 ± 0.008^*	0.068 ± 0.011	0.067 ± 0.008	0.444 ± 0.110
PQ high-dose	1.052 ± 0.087^*	1.097 ± 0.104^*	0.072 ± 0.012^*	0.066 ± 0.011^*	0.067 ± 0.013	0.069 ± 0.012	0.427 ± 0.125
ATQ low-dose	1.137 ± 0.135^*	1.182 ± 0.171^*	0.069 ± 0.008^*	0.062 ± 0.009^*	0.072 ± 0.024	0.074 ± 0.018	0.516 ± 0.258
ATQ mid-dose	1.195 ± 0.140^*	1.267 ± 0.146^*	0.070 ± 0.012^*	0.063 ± 0.011^*	0.068 ± 0.019	0.067 ± 0.014	0.473 ± 0.089
ATQ high-dose	1.193 ± 0.114^*	1.247 ± 0.156^*	0.074 ± 0.010^*	0.065 ± 0.009^*	0.071 ± 0.016	0.079 ± 0.012	0.446 ± 0.077

^* Significantly different from the control group at P < 0.05. One-way ANOVA test was performed, followed by Dunnett’s test

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