Table 2 Differentially expressed up or downregulated proteins from male (a) and female (b) rat sera
(a) | Â | Â | Â | Â | Â | Â |
|---|---|---|---|---|---|---|
Description | UniProt ID | Gene | Location | Type(s) | Log2 FC | p - value |
H2A clustered histone 6 | Q4FZT6 | H2AC6 | Nucleus | other | 1.436 | 0.008 |
Heterogeneous nuclear ribonucleoprotein C, isoform CRAa | A0A0G2JXW4 | Â | Â | Â | 1.388 | 0.026 |
Ig-like domain-containing protein | D3ZEP5 | Â | Â | Â | 1.201 | 0.023 |
Ig-like domain-containing protein | D3ZAB3 | Â | Â | Â | 1.178 | 0.046 |
Secreted phosphoprotein 1 | P08721 | SPP1 | ES | cytokine | 1.139 | 0.006 |
Tsukushi, small leucine-rich proteoglycan | Q6QMY6 | TSKU | ES | other | 1.126 | 0.010 |
Ig kappa chain V-IV region-like | F1M1R0 | LOC690813 | Other | other | 1.037 | 0.026 |
Urinary protein 2 | P81828 | Â | Â | Â | 1.027 | 0.017 |
Urinary protein 3-like | M0R7P3 | Â | Â | Â | 1.002 | 0.001 |
Ig-like domain-containing protein | A0A0G2JXB7 | Â | Â | Â | 1.001 | 0.005 |
Urinary protein 2 | P81827 | LOC100360095 (includes others) | Other | other | 0.994 | 0.026 |
H1.2 linker histone, cluster member | A0A0G2K654 | H1f2 | Nucleus | other | 0.984 | 0.032 |
Ig-like domain-containing protein | M0R7Q2 | Â | Â | Â | 0.96 | 0.047 |
Cochlin | B1H259 | Coch | Cytoplasm | other | 0.94 | 0.008 |
Transcription factor binding to IGHM enhancer 3 | D3ZAW6 | TFE3 | Nucleus | TR | 0.869 | 0.015 |
Insulin-like growth factor-binding protein 6 | P35572 | IGFBP6 | ES | other | 0.835 | 0.018 |
Angiogenin | Q5GAM5 | ANG | ES | enzyme | 0.776 | 0.007 |
GM2 ganglioside activator | Q6IN37 | GM2A | Cytoplasm | enzyme | 0.772 | 0.023 |
CD5 molecule like | Q4KM75 | CD5L | PM | Tm. Rc. | 0.768 | 0.020 |
Similar to BC049975 protein | F1M8F5 | Â | Â | Â | -0.71 | 0.039 |
Mannosidase alpha class 1A member 1 | A0A0G2JW29 | MAN1A1 | Cytoplasm | enzyme | -0.732 | 0.026 |
Uncharacterised protein | M0R5J4 | Â | Â | Â | -0.746 | 0.015 |
Filamin A | C0JPT7 | FLNA | Cytoplasm | other | -0.754 | 0.016 |
NME/NM23 nucleoside diphosphate kinase 2 | P19804 | NME2 | Nucleus | kinase | -0.76 | 0.026 |
Ig-like domain-containing protein | M0RDF2 | Â | Â | Â | -0.762 | 0.009 |
Paraoxonase 1 | P55159 | PON1 | ES | phosphatase | -0.764 | 0.048 |
Serpin family D member 1 | A0A0G2K8K3 | SERPIND1 | ES | other | -0.786 | 0.026 |
RIKEN cDNA 1300017J02 gene | E9PST1 | 1300017J02Rik | ES | other | -0.811 | 0.022 |
Cytochrome c, somatic | P62898 | CYCS | Cytoplasm | transporter | -0.812 | 0.020 |
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | A0A0G2JV65 | YWHAZ | Cytoplasm | enzyme | -0.818 | 0.027 |
Tropomyosin 3 | Q63610 | Tpm3 | Cytoplasm | other | -0.821 | 0.034 |
Histidine-rich glycoprotein | A0A0G2K3G0 | Hrg | Cytoplasm | other | -0.824 | 0.050 |
Serpin family A member 6 | P31211 | SERPINA6 | ES | other | -0.837 | 0.033 |
Profilin 1 | P62963 | PFN1 | Cytoplasm | other | -0.845 | 0.021 |
Integrin subunit beta 1 | A0A0G2JSK5 | ITGB1 | PM | Tm. Rc. | -0.85 | 0.001 |
Serine protease 3 | D3ZQV0 | PRSS3 | ES | peptidase | -0.852 | 0.002 |
Caveolae associated protein 2 | Q66H98 | CAVIN2 | PM | other | -0.862 | 0.040 |
Cofilin 1 | P45592 | CFL1 | Nucleus | other | -0.863 | 0.005 |
Carboxylesterase 1C | D3ZGK7 | Ces1c | ES | enzyme | -0.866 | 0.027 |
Complement component 4 binding protein alpha | Q63514 | C4BPA | ES | other | -0.878 | 0.003 |
Phosphoglycerate kinase 1 | P16617 | PGK1 | Cytoplasm | kinase | -0.88 | 0.002 |
FYN binding protein 1 | D3ZIE4 | FYB1 | Nucleus | other | -0.883 | 0.037 |
Tubulin beta class I | P69897 | TUBB | Cytoplasm | other | -0.888 | 0.015 |
Thymosin beta 4 X-linked | P62329 | TMSB10/TMSB4X | Cytoplasm | other | -0.907 | 0.047 |
Complement C1s | G3V7L3 | C1S | ES | peptidase | -0.911 | 0.049 |
Alpha-1-B glycoprotein | Q9EPH1 | A1BG | ES | other | -0.921 | 0.016 |
Carboxylesterase 1C | P10959 | Ces1c | ES | enzyme | -0.951 | 0.043 |
Inter-alpha-trypsin inhibitor heavy chain 4 | Q5EBC0 | ITIH4 | ES | other | -0.964 | 0.005 |
Serglycin | P04917 | Srgn | Cytoplasm | other | -0.981 | 0.012 |
Cysteine- and glycine-rich protein 1 | P47875 | CSRP1 | Nucleus | other | -0.984 | 0.022 |
Haemoglobin subunit beta-2-like | Q62669 | LOC103694855 | Other | other | -1.014 | 0.020 |
Glutathione peroxidase 3 | A0A0G2K531 | GPX3 | ES | enzyme | -1.02 | 0.022 |
Thioredoxin | R4GNK3 | TXN | Cytoplasm | enzyme | -1.034 | 0.003 |
Ig-like domain-containing protein | F1LWD0 | Â | Â | Â | -1.072 | 0.001 |
Pleckstrin | A0A0G2K393 | PLEK | Cytoplasm | other | -1.119 | 0.003 |
Cyclase associated actin cytoskeleton regulatory protein 1 | Q08163 | CAP1 | PM | other | -1.131 | 0.011 |
Phospholipid transfer protein | E9PSP1 | PLTP | ES | enzyme | -1.151 | 0.047 |
Ceruloplasmin | G3V7K3 | CP | ES | enzyme | -1.152 | 0.002 |
Tropomyosin 4 | P09495 | Tpm4 | Cytoplasm | other | -1.153 | 0.003 |
Serpin family A member 10 | Q62975 | SERPINA10 | ES | other | -1.178 | 0.001 |
Actin beta | A0A0G2K3K2 | ACTB | Cytoplasm | other | -1.211 | 0.020 |
Tubulin beta 1 class VI | M0R8B6 | TUBB1 | Cytoplasm | other | -1.217 | 0.011 |
Transgelin 2 | Q5XFX0 | TAGLN2 | Cytoplasm | other | -1.269 | 0.008 |
Carboxypeptidase N subunit 2 | F1LQT4 | CPN2 | ES | peptidase | -1.297 | 0.004 |
Complement component 4 binding protein beta | A0A5C5 | C4BPB | ES | other | -1.334 | 0.002 |
Ig-like domain-containing protein | F1LYQ4 | Â | Â | Â | -1.365 | 0.014 |
Calponin 2 | D3ZRX9 | CNN2 | Cytoplasm | other | -1.389 | 0.017 |
Deleted in malignant brain tumours 1 | Q8CIZ5 | DMBT1 | PM | Tm. Rc. | -1.435 | 0.025 |
Lactate dehydrogenase A | P04642 | Ldha/RGD1562690 | Cytoplasm | enzyme | -1.597 | 0.008 |
Tubulin alpha 4a | Q5XIF6 | TUBA4A | Cytoplasm | other | -1.655 | 0.000 |
RAP1B, member of RAS oncogene family | Q62636 | RAP1B | Cytoplasm | enzyme | -1.671 | 0.001 |
Complement C8 beta chain | P55314 | C8B | ES | other | -1.743 | 0.013 |
Actin alpha 1, skeletal muscle | P68136 | ACTA1 | Cytoplasm | other | -2.257 | 0.011 |
H2A.Z variant histone 2 | D4AEC0 | H2AZ2 | Nucleus | other | -2.287 | 0.003 |
(b) | Â | Â | Â | Â | Â | Â |
Description | UniProt ID | Gene | Location | Type(s) | Log10 FC | p -value |
Ig-like domain-containing protein | M0RD98 | Â | Â | Â | 2.871 | 0.004 |
Ig-like domain-containing protein | M0RDL2 | Â | Â | Â | 2.002 | 0.037 |
Ig-like domain-containing protein | M0R8G6 | Â | Â | Â | 1.849 | 0.010 |
Ig-like domain-containing protein | F1LTY5 | Â | Â | Â | 1.791 | 0.022 |
Ig-like domain-containing protein | F1M2W3 | Â | Â | Â | 1.708 | 0.046 |
Immunoglobulin kappa constant | P01836 | Igkc | ES | other | 1.621 | 0.024 |
Ig-like domain-containing protein | D3ZWC1 | Â | Â | Â | 1.591 | 0.029 |
Ig-like domain-containing protein | F1LW26 | Â | Â | Â | 1.549 | 0.028 |
Ig-like domain-containing protein | D3ZEP5 | Â | Â | Â | 1.521 | 0.036 |
Keratin 86 | A0A0G2QC11 | KRT86 | Cytoplasm | other | 1.301 | 0.012 |
Ig-like domain-containing protein | A0A0G2K7S9 | Â | Â | Â | 1.194 | 0.044 |
Ig-like domain-containing protein | M0RBK4 | Â | Â | Â | 1.16 | 0.032 |
Keratin 87 | A7M746 | Krt87 | ES | other | 1.154 | 0.045 |
Lipopolysaccharide binding protein | Q63313 | LBP | PM | transporter | 1.02 | 0.001 |
Insulin-like growth factor-binding protein 4 | P21744 | IGFBP4 | ES | other | 0.984 | 0.050 |
Glycoprotein V platelet | G3V9H9 | NEWGENE_2724 | Other | other | 0.976 | 0.010 |
Transferrin | P12346 | TF | ES | transporter | 0.904 | 0.015 |
Carboxypeptidase B2 | Q9EQV9 | CPB2 | ES | peptidase | 0.719 | 0.049 |
Vinculin | A0A0G2K8V2 | VCL | PM | enzyme | -0.901 | 0.045 |
Proteasome 20S subunit alpha 5 | P34064 | PSMA5 | Cytoplasm | peptidase | -0.906 | 0.025 |
Heat shock protein family A (Hsp70) member 5 | P06761 | HSPA5 | Cytoplasm | enzyme | -0.989 | 0.032 |
Proteasome 20S subunit beta 1 | P18421 | PSMB1 | Cytoplasm | peptidase | -1.11 | 0.002 |
Coagulation factor X | Q63207 | F10 | ES | peptidase | -1.147 | 0.023 |
Filamin A | C0JPT7 | FLNA | Cytoplasm | other | -1.266 | 0.018 |
Peroxiredoxin 5 | Q9R063 | PRDX5 | Cytoplasm | enzyme | -1.449 | 0.050 |
Thymosin beta 4 X-linked | P62329 | TMSB10/TMSB4X | Cytoplasm | other | -1.472 | 0.011 |
Ig-like domain-containing protein | F1LWW1 | Â | Â | Â | -1.515 | 0.039 |
Complement C8 beta chain | P55314 | C8B | ES | other | -1.561 | 0.037 |
DExH-box helicase 9 | D4A9D6 | DHX9 | Nucleus | enzyme | -1.655 | 0.040 |
ATP synthase F1 subunit beta | P10719 | ATP5F1B | Cytoplasm | transporter | -1.731 | 0.032 |
Lactate dehydrogenase A | P04642 | Ldha/RGD1562690 | Cytoplasm | enzyme | -1.756 | 0.003 |
40S ribosomal protein S26 | A0A0G2JY64 | Â | Â | Â | -1.831 | 0.017 |
Uncharacterised protein | D3ZM33 | Â | Â | Â | -1.839 | 0.026 |
Tropomyosin 4 | P09495 | Tpm4 | Cytoplasm | other | -1.971 | 0.007 |
Ribosomal protein L15 | P61314 | RPL15 | Cytoplasm | other | -2.041 | 0.013 |
Prohibitin | P67779 | PHB | Nucleus | TR | -2.05 | 0.010 |
Ribosomal protein SA | P38983 | RPSA | Cytoplasm | TR | -2.062 | 0.018 |
Ribosomal protein L18a | P62718 | RPL18A | Cytoplasm | other | -2.065 | 0.026 |
X-ray repair cross-complementing 6 | Q6AZ64 | XRCC6 | Nucleus | enzyme | -2.12 | 0.007 |
Eukaryotic translation initiation factor 4A1 | Q6P3V8 | EIF4A1 | Cytoplasm | TR | -2.213 | 0.006 |
Chaperonin containing TCP1 subunit 2 | Q5XIM9 | CCT2 | Cytoplasm | kinase | -2.231 | 0.025 |
Ubiquitin A-52 residue ribosomal protein fusion product 1 | P62986 | Uba52 | Cytoplasm | other | -2.232 | 0.005 |
H3.3 histone A | P84245 | H3-3A/H3-3B | Nucleus | other | -2.252 | 0.038 |
Receptor for activated C kinase 1 | P63245 | RACK1 | Cytoplasm | enzyme | -2.326 | 0.009 |
Threonyl-tRNA synthetase 1 | Q5XHY5 | TARS1 | Nucleus | enzyme | -2.661 | 0.012 |