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Table 3 The specific information of the top 10 core targets from topological analysis of 246 targets

From: Pharmacological mechanism and therapeutic efficacy of Icariside II in the treatment of acute ischemic stroke: a systematic review and network pharmacological analysis

Gene symbol

Protein name

Degree (DC)

SRC

Proto-oncogene tyrosine-protein kinase Src

46

CTNNB1

Catenin beta-1

40

HSP90AA1

Heat shock protein HSP 90-alpha

35

MAPK1

Mitogen-activated protein kinase 1

34

RELA

Transcription factor p65

34

ESR1

Estrogen receptor, ER

33

PI3KCA

Phosphatidylinositol-4,5-bisphosphate 3-kinase

32

AKT1

RAC-alpha serine/threonine-protein kinase

26

EGFR

Epidermal growth factor receptor

25

RHOA

Transforming protein RhoA

25