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Fig. 7 | BMC Complementary Medicine and Therapies

Fig. 7

From: Novel mechanism of napabucasin, a naturally derived furanonaphthoquinone: apoptosis and autophagy induction in lung cancer cells through direct targeting on Akt/mTOR proteins

Fig. 7

Molecular docking of NB and mTORC1 and mTORC2 compared to reference compound. (A) The 3D binding site of NB and ATP in complex with mTORC1 at the catalytic site. ATP-mTORC1 complex and NB-mTORC1 complex. (B) Docking energy of NB and mTORC1 compared to reference compound. (C) The 3D binding site of NB and ATP in complex with mTORC2 at the catalytic site. ATP-mTORC2 complex and NB-mTORC2 complex. The blue dashed lines denoted hydrogen-bonding interaction. (D) Docking energy of NB and mTORC2 compared to reference compound

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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