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Fig. 6 | BMC Complementary Medicine and Therapies

Fig. 6

From: Novel mechanism of napabucasin, a naturally derived furanonaphthoquinone: apoptosis and autophagy induction in lung cancer cells through direct targeting on Akt/mTOR proteins

Fig. 6

Molecular docking of NB and Akt compared to reference compound. (A) The 3D binding site of NB and reference compound at the active site. (B) Akt in complexed with reference compound and Akt in complexed with NB at the active site. The blue dashed lines denoted hydrogen-bonding interaction. (C) The 3D binding site of NB and 4IP at the PIP3-cavity within the PH-domain. (D) PH domain of Akt in complexed with 4IP and PH domain of Akt in complexed with NB. The blue dashed lines denoted hydrogen-bonding interaction. (E) Docking energy of NB and Akt compared to references

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