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Table 4 Changes in pharmacodynamics (PD) parameters of control and after administration of GEE, EEE, SEE, and acarbose with sucrose or starch ingestions

From: Selected coffee (Coffea arabica L.) extracts inhibit intestinal α-glucosidases activities in-vitro and postprandial hyperglycemia in SD Rats

Groups

PD Parameters

Cmax (mg/dL)

Tmax (hr)

AUCt (hr·mg/dL)

Sucrose 2.0 g/kg

222.3 ± 16.0

0.7 ± 0.3

516.0 ± 29.0

Acarbose 5.0 mg/kg

137.4 ± 8.3***

0.8 ± 0.3

376.2 ± 17.2***

GEE 0.5 g/kg

188.7 ± 13.5**

0.8 ± 0.3

480.7 ± 34.1

EEE 0.5 g/kg

194.1 ± 18.3*

0.7 ± 0.3

483.6 ± 27.6

SEE 0.5 g/lg

185.9 ± 8.9**

0.9 ± 0.2

481.4 ± 11.8

Starch 2.0 g/kg

236.2 ± 25.1

0.5 ± 0.0

529.1 ± 13.4

Acarbose 5.0 mg/kg

144.1 ± 18.8***

1.3 ± 0.5**

389.0 ± 36.8***

GEE 0.5 g/kg

188.0 ± 25.7*

0.6 ± 0.2

454.9 ± 46.7*

EEE 0.5 g/kg

195.0 ± 13.9**

0.7 ± 0.3

477.8 ± 34.5*

SEE 0.5 g/lg

203.4 ± 14.5*

0.8 ± 0.3*

468.2 ± 37.0**

  1. The results were expressed as mean ± S.D. All parameters were compared between control and treatment group (GEE, EEE, SEE, and Acarbose) by unpaired Student’s t-test (*p < 0.05; **p < 0.01; and ***p < 0.001)