Fig. 1

Guduchi and Madhuyashti feeding exaggerate polyQ mediated neurodegeneration in GMR-GAL4 > UAS-127Q/CyO-GFP flies. A Eyes classified into mild (b), moderate (c) and severe (d) types in comparison to normal wild type (a). Nail polish imprints of wild-type eyes (e) showing proper ommatidial organization, which was disrupted in mild (f), moderate (g) and severe (h) categories. B Histogram showing mean percentage (+SD) for the eye phenotype mild (purple), moderate (red) and severe (green) in GMR-GAL4 > UAS-127Q/CyO-GFP flies when grown on regular food, Guduchi and Madhuyashti. Y-axis represents percentage of eyes observed for each phenotype and X-axis represents different feeding regimes. Scale bar in a represents 100 μm and applies from a-h. ** represents P ≤ 0.001 using Student’s t-test