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Fig. 7 | BMC Complementary Medicine and Therapies

Fig. 7

From: Pulsatilla decoction suppresses matrix metalloproteinase-7-mediated leukocyte recruitment in dextran sulfate sodium-induced colitis mouse model

Fig. 7

MMP-7 participates in the molecular mechanism underlying PD in the DSS-induced colitis mouse model. (A) In the DSS-induced colitis mouse model, MMP-7 induces the infiltration of neutrophils and macrophages by generating a CXCL1/KC chemokine gradient and release of TNF-α from macrophages. (B) The administration of PD significantly inhibits the activities of MMP-7 and thereby suppresses the infiltration of neutrophils and macrophages as well as the intestinal inflammation in the DSS-induced colitis mouse model

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