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Fig. 2 | BMC Complementary Medicine and Therapies

Fig. 2

From: Harpagoside attenuates local bone Erosion and systemic osteoporosis in collagen-induced arthritis in mice

Fig. 2

Effect of harpagoside (HAR) on the severity of arthritis and histopathological changes in collagen-induced arthritis (CIA) mice. On day 42 after the initial immunization with Col 2, systemic bone loss was analyzed by micro-CT, and bone destruction and cartilage damage of CIA mice were analyzed by histological staining of the ankle joint. A Representative 3D images of the hind paw (up) and calcaneus (down). B The total porosity, trabecular thickness (Tb.Th), and trabecular pattern factor (Tb.Pf) of the calcaneus. C The ankle joint was sectioned and stained with H&E, TRAP, Safranin O, and toluidine blue. Scale bar, 100 μm. D The pathological severity scores of inflammation, pannus formation, cartilage damage, and bone damage in the ankle joint of CIA mice. E The number of osteoclasts per field was counted using the histomorphometric methods. **p < 0.01 and ***p < 0.001 versus the normal group; # p < 0.05, ##p < 0.01, and ###p < 0.001 versus the CIA + PBS group

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