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Fig. 1 | BMC Complementary Medicine and Therapies

Fig. 1

From: Harpagoside attenuates local bone Erosion and systemic osteoporosis in collagen-induced arthritis in mice

Fig. 1

Effect of harpagoside (HAR) on the progression of collagen-induced arthritis (CIA). A Study design to induce CIA in mice. Eight-week-old male DBA/1 mice were first immunized with Col 2 and CFA on day 0 and then immunized intraperitoneally with Col 2 on day 21. Next, booster injection with LPS was given on day 28. CIA mice were orally administrated with HAR (10 mg/kg) every day from day 16 to 42 in the prevention group and from day 28 to 42 in the therapy group. B Representative photographs of normal, PBS-, and HAR-treated CIA mice. C The incidence of arthritis, D clinical scores, and E body weight change were determined on the indicated days. ***p < 0.001 versus the normal group; ##p < 0.01 and ###p < 0.001 versus the CIA + PBS group

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