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Fig. 4 | BMC Complementary Medicine and Therapies

Fig. 4

From: Rhein promotes the proliferation of keratinocytes by targeting oestrogen receptors for skin ulcer treatment

Fig. 4

Effects of Rhein on estrogen signaling pathway and c-myc expression under the intervention of estrogen antagonists in HaCaT. A cytotoxicity of Estrogen antagonist (ICI 182,780) were measured by CCK-8 assays. B–E C-myc, FosB, and JunD protein expression in HaCaT with rhein at 50 μM concentration. F–H The mRNA levels of c-myc, FosB, and JunD in HaCaT with rhein at 50 μM concentration. Full-length blots are shown in Supplementary Fig. S1. Data are presented as the mean ± SEM. *P < 0.05 and **P < 0.01 versus the DMSO group, ##P < 0.01 versus the rhein group

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