Table 5 Toxicokinetic parameters of 6 components in rat plasma on the first and 28th day treated with TAZF

berberine

Day 1

58.92

221.60 ± 179.72

148.77 ± 72.99

1222.27 ± 389.41

121.57 ± 17.07

176.76

299.00 ± 148.50

358.33 ± 119.60

1570.11 ± 389.90

554.10 ± 251.73

545.01

219.33 ± 24.42

218.70 ± 118.35

1860.60 ± 424.79

306.28 ± 94.72

Day 28

58.92

460.50 ± 275.96

324.10 ± 431.97

699.29 ± 643.96

838.44 ± 949.05

176.76

102.40 ± 33.71

19.10 ± 3.28

484.04 ± 91.68

115.09 ± 56.44

545.01

135.93 ± 77.87

23.83 ± 6.25

608.14 ± 203.22

153.27 ± 53.73

epiberberine

Day 1

5.48

21.05 ± 21.05

9.96 ± 4.38

94.67 ± 43.14

11.57 ± 1.08

16.44

25.37 ± 16.50

30.43 ± 15.40

201.57 ± 35.93

72.49 ± 26.67

50.69

33.23 ± 25.69

17.80 ± 7.13

265.36 ± 67.81

128.90 ± 48.41

Day 28

5.48

28.67 ± 33.82

23.34 ± 27.62

38.92 ± 10.07

75.82 ± 44.51

16.44

15.32 ± 8.98

14.50 ± 2.54

160.77 ± 34.73

138.58 ± 54.58

50.69

31.27 ± 7.23

30.37 ± 12.39

451.56 ± 79.31

311.25 ± 123.81

coptisine

Day 1

10.08

32.43 ± 33.02

18.11 ± 11.11

131.79 ± 55.97

9.49 ± 2.79

30.24

44.23 ± 25.22

50.00 ± 19.72

195.05 ± 48.20

63.81 ± 31.66

93.24

32.30 ± 9.08

31.07 ± 15.51

239.83 ± 65.50

57.11 ± 10.26

Day 28

10.08

45.49 ± 57.63

52.53 ± 72.46

17.32 ± 11.02

99.93 ± 135.02

30.24

14.92 ± 4.51

2.95 ± 2.29

60.21 ± 10.20

4.65 ± 4.06

93.24

20.05 ± 13.57

2.82 ± 0.87

81.65 ± 9.48

10.74 ± 6.60

palmatine

Day 1

12.56

52.47 ± 52.73

27.93 ± 13.97

236.12 ± 103.55

18.08 ± 4.07

37.68

71.53 ± 51.37

77.60 ± 35.30

318.68 ± 67.35

90.31 ± 50.76

116.18

51.33 ± 17.52

46.60 ± 27.16

342.51 ± 66.62

38.00 ± 16.92

palmatine

Day 28

12.56

67.20 ± 74.82

55.94 ± 72.88

36.98 ± 18.55

116.47 ± 138.20

37.68

22.63 ± 3.35

4.16 ± 0.97

102.21 ± 20.79

14.65 ± 10.78

116.18

32.93 ± 24.17

5.67 ± 2.58

110.18 ± 34.30

24.07 ± 12.21

jatrorrhizine

Day 1

1.88

11.85 ± 10.79

11.04 ± 7.79

51.95 ± 20.41

25.63 ± 30.02

5.64

15.41 ± 10.60

14.64 ± 6.91

74.52 ± 18.30

19.94 ± 9.16

17.39

17.66 ± 10.96

14.84 ± 10.66

101.24 ± 35.32

22.12 ± 4.83

Day 28

1.88

16.40 ± 15.98

11.15 ± 15.03

8.62 ± 3.21

23.94 ± 27.68

5.64

7.78 ± 1.76

1.29 ± 0.31

33.28 ± 3.59

3.87 ± 1.24

17.39

7.97 ± 7.64

2.08 ± 0.41

25.64 ± 6.74

11.36 ± 1.79

columbamine

Day 1

3.80

32.13 ± 28.69

29.98 ± 20.67

152.81 ± 54.87

71.44 ± 80.14

11.40

41.70 ± 28.23

39.63 ± 18.46

206.76 ± 40.77

59.20 ± 20.55

35.15

46.47 ± 30.26

37.70 ± 30.37

275.76 ± 91.98

41.10 ± 10.03

Day 28

3.80

44.17 ± 42.31

30.29 ± 40.03

31.11 ± 2.21

68.10 ± 76.87

11.40

21.37 ± 4.71

1.35 ± 0.97

90.56 ± 9.79

9.42 ± 7.32

35.15

16.44 ± 11.77

2.98 ± 0.24

65.14 ± 6.74

12.23 ± 4.52