Sample | Code | %yield (w/w) | IC50 µg/mL ± SEM and Selective index (SI) | ||
---|---|---|---|---|---|
HepG2 | KKU-M156 | HaCat | |||
Fraction 1 (hexane) | F1 | 0.19 | NT | NT | NT |
Fraction 2 (hexane: CHCl3, 1:1) | F2 | 2.31 | > 100**** | > 100**** | > 100**** |
Fraction 3 (CHCl3) | F3 | 14.57 | 43.14 ± 1.50**** (SI = 2.2) | 42.26 ± 1.07**** (SI = 2.2) | 92.96 ± 2.22**** |
Fraction 4 (CHCl3: MeOH, 1:1) | F4 | 78.65 | 51.95 ± 0.37**** (SI = 1.8) | 61.51 ± 5.08**** (SI = 1.5) | 95.01 ± 0.42**** |
Fraction 5 (MeOH) | F5 | 4.27 | > 100**** | > 100**** | > 100**** |
Loureirin B (1) | P1 | 0.10 | 20.02 ± 0.46**** (SI = 4.3) | 21.26 ± 3.17*** (SI = 4.1) | 86.12 ± 2.13**** |
4-Hydroxy-2,4’-dimethoxydihydrochalcone (2) | P2 | 0.12 | 20.71 ± 0.49**** (SI = 3.2) | 33.21 ± 2.10**** (SI = 2.0) | 66.00 ± 0.68**** |
Eucomol (3) | P3 | 0.15 | 25.76 ± 1.56**** (SI = 1.8) | 7.12 ± 0.56**** (SI = 6.5) | 46.55 ± 0.88**** |
EtOH of D.cochinchinensis | DC95 | 10.45 | 7.72 ± 1.87**** (SI = 5.2) | 5.27 ± 5.01**** (SI = 7.7) | 40.47 ± 0.39**** |
Vincristine sulfate | - | - | 0.012 ± 0.0005 (SI = 0.00058) | 0.0026 ± 0.001 (SI = 0.0026) | 0.000007 ± 0.00 |