Table 5 Topological metrics analysis of network

1

MAPK 1

24

0.53125

0.15264486

2

MAPK 10

18

0.47222222

0.06938654

3

MAPK 14

14

0.4047619

0.03426261

4

TNF

12

0.3984375

0.02919505

5

Pathways in cancer

10

0.43965517

0.09264678

6

MAPK signaling pathway

10

0.49038462

0.06359126

7

INS

10

0.38059701

0.01816986

8

VEGFA

8

0.3984375

0.0178217

9

TGF-beta signaling pathway

7

0.46363636

0.04071533

10

FASN

7

0.39230769

0.01303181

11

TNF signaling pathway

6

0.45535714

0.01066349

12

Metabolism of xenobiotics by cytochrome P450

5

0.45535714

0.06255236

13

hepatocellular carcinoma

5

0.45535714

0.03820949

14

Oocyte meiosis

5

0.44736842

0.02674978

15

GSTM 1

5

0.36428571

0.01750897

16

GSTM 2

5

0.36428571

0.01750897

17

MGST 1

5

0.36428571

0.01750897

18

Non-alcoholic fatty liver disease

5

0.44736842

0.00885468

19

Insulin signaling pathway

5

0.44736842

0.00812833

20

Apoptosis

5

0.44736842

0.00743339

21

Type II diabetes mellitus

5

0.44736842

0.00686433

22

Progesterone-mediated oocyte maturation

5

0.44736842

0.00659734

23

Prolactin signaling pathway

5

0.44736842

0.00659734

24

Fc epsilon R I signaling pathway

5

0.44736842

0.00553748

25

IL-17 signaling pathway

5

0.44736842

0.00553748

26

Toll-like receptor signaling pathway

5

0.44736842

0.00553748

27

NOD-like receptor signaling pathway

5

0.44736842

0.00553748

28

Tyrosine metabolism

4

0.43220339

0.11529412

29

Amyotrophic lateral sclerosis

4

0.43220339

0.04152907

30

Glutathione metabolism

4

0.44736842

0.02333667

31

Prostate cancer

4

0.43965517

0.01329679

32

mTOR signaling pathway

4

0.43965517

0.00569641

33

PI3K-Akt signaling pathway

4

0.43965517

0.00569641

34

VEGF signaling pathway

4

0.43965517

0.00551107

35

Pancreatic cancer

4

0.43965517

0.00455056

36

Ras signaling pathway

4

0.43965517

0.00455056

37

T cell receptor signaling pathway

4

0.43965517

0.00387705

38

Th1 and Th2 cell differentiation

4

0.43965517

0.00311393

39

GnRH signaling pathway

4

0.43965517

0.00311393

40

AR

3

0.35915493

0.00368863

41

BMP 4

3

0.36956522

0.00260806

42

RIG-I-like receptor signaling pathway

3

0.43220339

0.00193453

43

Drug metabolism

3

0.27419355

4.71E-04

44

BMP 5

2

0.34931507

7.81E-04

45

PGR

2

0.34

5.39E-04

46

drug metabolism

1

0.41129032

0

47

AKR1C1

1

0.31481481

0

48

TYR

1

0.30357143

0

49

TPO

1

0.30357143

0

50

TAT

1

0.30357143

0

51

CAT

1

0.30357143

0