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Table 4 MICs of antibiotics in association with phytochemical 8 against selected bacteria

From: Antibacterial and antibiotic-potentiation activity of the constituents from aerial part of Donella welwitshii (Sapotaceae) against multidrug resistant phenotypes

Antibiotics

Concentrations of compound 8

Bacterial strain, MIC (μg/mL) and AMF (in bracket)

E. coli

P. aeruginosa

K. pneumoniae

  

ATCC10536

AG102

PA01

PA124

ATCC11296

KP55

STR

0

8

16

64

32

16

4

MIC/2

0.25(32)

4(4)

16(4)

16(2)

32(2)

2(2)

MIC/4

0.5(16)

16(1)

32(2)

32(1)

32(2)

2(2)

ERY

0

8

4

16

16

32

8

MIC/2

4(2)

0.5(8)

4(4)

8(2)

4(8)

4(2)

MIC/4

4(2)

1(4)

8(2)

16(1)

16(2)

8(1)

NOR

0

32

2

16

8

32

16

MIC/2

8(4)

0.25(8)

4(4)

2(4)

1(32)

4(4)

MIC/4

8(4)

0.5(4)

16(1)

2(4)

4(8)

4(4)

CIP

0

8

4

8

16

8

8

MIC/2

0.25(32)

0.25(16)

0.25(32)

1(16)

0.5(16)

0.25(32)

MIC/4

0.25(32)

0.25(16)

1(8)

4(4)

2(4)

1(8)

AMP

0

4

4

32

16

8

8

MIC/2

0.5(8)

2(1)

16(2)

4(4)

8(1)

4(2)

MIC/4

0.5(8)

2(1)

16(2)

8(2)

8(1)

4(2)

DOX

0

2

8

8

8

16

8

MIC/2

0.125(8)

0.5(16)

2(4)

0.5(16)

0.5(32)

2(4)

MIC/4

0.25(4)

1(8)

4(2)

2(4)

0.5(32)

4(2)

  1. Antibiotics tested at 256 μg/mL [STR streptomycin, ERY Erythromycin, NOR Norfloxacin, AMP ampicillin, CIP Ciprofloxacin, DOX Doxycycline, CHL Chloramphenicol, TET Tetracycline]. MIC Minimal Inhibitory Concentrations; Values in bold represent significant antibacterial activity and significant antibiotic-modulating factor (AMF). AMF ≥2 was set as the cut-off for biologically significance of antibiotic resistance modulating effects [27]