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Table 2 MIC (in μg/mL) of phytochemicals and chloramphenicol in combination of PAβN against a panel of 13 bacterial strains

From: Antibacterial and antibiotic-potentiation activity of the constituents from aerial part of Donella welwitshii (Sapotaceae) against multidrug resistant phenotypes

Bacterial strains

Tested Samples, MIC values in the presence of absence of PaβN (in μg/mL)

1

2

3

4

6

7

8

9

10

CHL

MIC

(+PAβN)

R

MIC (+PAβN)

R

MIC (+PAβN)

R

MIC (+PAβN)

R

MIC (+PAβN)

R

MIC (+PAβN)

R

MIC

(+PAβN)

R

MIC (+PAβN)

R

MIC (+PAβN)

R

MIC (+PAβN)

R

E. coli

 ATCC10536

256 (8)

32

–

–

–

–

128 (4)

32

126 (8)

16

64 (2)

32

32 (0.5)

64

64 (2)

32

128 (4)

32

8 (0.125)

64

 AG102

256 (16)

16

–

–

–

–

512 (16)

32

16 (1)

16

4 (0.125)

32

16 (0.5)

32

8 (0.5)

16

128 (8)

16

8 (0.125)

64

E. aerogenes

 ATCC13048

128 (8)

16

256 (4)

4

256 (8)

32

512 (8)

64

128 (2)

64

8 (0.5)

16

64 (1)

64

16 (0.25)

64

–

–

4 (0.25)

16

 EA27

512 (8)

4

512 (8)

8

512 (16)

32

256 (8)

32

32 (1)

32

32 (1)

32

8 (0.25)

32

8 (0.125)

64

–

–

8 (0.125)

64

K. pneumoniae

 ATCC11296

256 (16)

8

256 (8)

4

256 (16)

16

–

–

16 (2)

8

32 (2)

16

4 (0.25)

16

64 (1)

64

128 (16)

8

4 (0.5)

8

 KP55

256 (8)

8

512 (8)

4

512 (16)

32

–

–

16 (0.5)

32

4 (0.25)

16

128 (4)

32

32 (1)

32

512 (8)

64

8 (0.125)

64

P. stuartii

 PS2636

128 (4)

4

512 (16)

2

512 (8)

64

256 (16)

16

128 (16)

8

32 (0.5)

64

64 (2)

32

8 (0.125)

64

128 (16)

8

8 (0.25)

32

 NEA16

512 (16)

8

512 (32)

4

512 (16)

32

128 (16)

8

32 (2)

16

8 (0.25)

32

128 (2)

64

128 (8)

16

64 (4)

16

8 (0.125)

64

P. aeruginosa

 PA01

–

–

–

2

–

–

–

–

256 (8)

32

32 (1)

32

128 (4)

32

64 (2)

32

128 (8)

16

4 (1)

4

 PA124

–

–

–

2

–

–

–

–

256 (32)

8

32 (0.5)

64

64 (1)

64

32 (0.5)

64

128 (4)

32

4 (0.5)

8

S. aureus

 ATCC25923

128 (4)

4

128 (16)

1

512 (8)

64

128 (8)

16

128 (8)

16

32 (1)

32

64 (2)

32

128 (2)

64

512 (8)

64

2 (2)

1

 MRSA3

512 (8)

1

128 (8)

4

512 (16)

32

64 (2)

32

512 (16)

32

8 (0.125)

64

128 (2)

64

128 (8)

16

–

–

4 (4)

1

 MRSA6

256 (8)

1

128 (8)

1

512 (16)

32

256 (16)

16

64 (4)

16

64 (2)

32

8 (0.25)

32

128 (4)

32

–

–

4 (4)

1

  1. MIC Minimal inhibitory concentration, PAßN Phenylalanine arginyl β-Naphtylamide, R Ameliorating Factor: MIC sample alone/MIC sample + PAβN ratio (this means the factor which determines the improvement of the activity of samples by PAβN; the activity of a sample was improved when its AIF was > 2); (−): MIC > 512 μg/mL for compound