Fig. 1

Effects of BZXD on the CIA rats. A Clinical scores index, B Paw thickness, C Body weight change was measured at 0, 7, 14, 21, 28, 35 and 42 days (n = 10 rats per group, two-way repeated-measures ANOVA followed by Fisher’s LSD test). D Serum inflammatory cytokines were measured 28 and 42 days by ELISA (n = 4 rats per group, one-way ANOVA followed by Fisher’s LSD test). E Representative images of different degrees of arthritis in rats. Data are presented as mean ± SD, *P < 0.05, **P < 0.01 CIA versus Control; #P < 0.05 ##P < 0.01 BZXD versus CIA