Fig. 3

Protein–protein interaction network of therapeutic targets. a Is the original PPI network of therapeutic targets and all nodes in the network are green. In b, the core nodes in this network screened by their topological features are yellow, and the other nodes are green. c Is the sub-network constructed from the core nodes of (b), the core nodes in this network screened by their topological features are yellow, and the other nodes are green. d Is the sub-network constructed from the core nodes of (c), all nodes in the network are yellow and represent the final central therapeutic targets obtained through screening