Fig. 1

Active ingredients and core targets screening. A. The volcano plot displayed the significance and the fold change of differentially expressed genes acquired from the GEO database; The red ones represented up-regulated DEGs (log2(fold change) > 1), while the green ones represented down-regulated DEGs (log2(fold change) < − 1). B. The Venn diagram demonstrates the overlapping of network pharmacology-based targets of QHF components (red color) and transcriptionally dysregulated genes of B-cell lymphoma (turquoise color). C. The Protein-Protein-Interaction (PPI) network of the core genes. D. The core targets and their node degrees. E. The herb-target chord chart displays the relationship of the most involved targets and herbs. F. The drug-disease-target network indicated the relationship between the drugs, compounds, and targets. The pink triangles of the left peripheral circle represented the compounds of QHF, while the four orange octagons represented the four herbs of QHF. The blue arrows of the right peripheral circle represented the core targets of B cell lymphoma