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Table 5 Serum biochemical parameters in males and females after 28Ā days of administration

From: Cytotoxicity, acute and sub-chronic toxicities of the fruit extract of Tetrapleura tetraptera (Schumm. & Thonn.) Taub. (Fabaceae)

Doses (mg/Kg)

Female

Male

0

250

500

1000

0

250

500

1000

Creatinine (mg/dL)

0.78ā€‰Ā±ā€‰0.02a

0.78ā€‰Ā±ā€‰0.05a

0.85ā€‰Ā±ā€‰0.05a

0.84ā€‰Ā±ā€‰0.03a

1.44ā€‰Ā±ā€‰0.03c

1.33ā€‰Ā±ā€‰0.02b

1.27ā€‰Ā±ā€‰0.01a

1.28ā€‰Ā±ā€‰0.02a

Urea (mg/dL)

71.23ā€‰Ā±ā€‰3.35a

71.23ā€‰Ā±ā€‰1.58a

73.80ā€‰Ā±ā€‰7.27a

87.35ā€‰Ā±ā€‰2.56b

62.35ā€‰Ā±ā€‰0.78a

70.48ā€‰Ā±ā€‰0.98b

72.29ā€‰Ā±ā€‰2.25bc

74.25ā€‰Ā±ā€‰1.86c

ASAT (U/L)

107.18ā€‰Ā±ā€‰2.31b

106.96ā€‰Ā±ā€‰1.49b

94.62ā€‰Ā±ā€‰2.57a

97.56ā€‰Ā±ā€‰1.82a

105.43ā€‰Ā±ā€‰2.31c

84.43ā€‰Ā±ā€‰3.23b

73.71ā€‰Ā±ā€‰2.61a

73.06ā€‰Ā±ā€‰1.12a

ALAT (U/L)

61.19ā€‰Ā±ā€‰1.82b

57.31ā€‰Ā±ā€‰1.13a

57.75ā€‰Ā±ā€‰1.43a

57.09ā€‰Ā±ā€‰1.31a

65.19ā€‰Ā±ā€‰2.08c

57.53ā€‰Ā±ā€‰1.66b

53.81ā€‰Ā±ā€‰2.53a

54.03ā€‰Ā±ā€‰1.49a

PAL (U/L)

363.43ā€‰Ā±ā€‰3.12d

308.26ā€‰Ā±ā€‰1.49c

261.29ā€‰Ā±ā€‰3.12b

200.18ā€‰Ā±ā€‰1.75a

420.43ā€‰Ā±ā€‰2.35c

376.66ā€‰Ā±ā€‰2.35b

373.46ā€‰Ā±ā€‰3.12b

352.94ā€‰Ā±ā€‰2.35a

Total Protein (g/dL)

8.70ā€‰Ā±ā€‰0.29b

7.66ā€‰Ā±ā€‰0.22a

7.37ā€‰Ā±ā€‰0.58a

7.02ā€‰Ā±ā€‰0.42a

10.31ā€‰Ā±ā€‰0.07b

9.13ā€‰Ā±ā€‰0.85a

8.38ā€‰Ā±ā€‰0.70a

7.92ā€‰Ā±ā€‰0.59a

  1. Data are expressed as meanā€‰Ā±ā€‰SD, nā€‰=ā€‰4. Values in the test groups carrying the same letter as the control group in the same gender and in the same row are not significantly different according to Waller Duncanā€™s Multiple Comparison Test (pā€‰<ā€‰0.05). ASAT Aspartate amino transferase, ALAT Alanine amino transferase, PAL Phosphatase alkaline