Skip to main content

Table 3 Effect of CisPT and different treatments of AHE on brain GSH profile and phase II antioxidants

From: Reversal of cisplatin triggered neurotoxicity by Acacia hydaspica ethyl acetate fraction via regulating brain acetylcholinesterase activity, DNA damage, and pro-inflammatory cytokines in the rodent model

Treatment (mg/kg)

GSH (µM/g tissue)

GR (nM/min/mg protein)

GST (nM/min/mg protein)

γ-GT (nM/min/mg Protein)

GPx (nM/min/mg Protein)

Control

18.01 ± 0.529+++

155.4 ± 0.625+++

139.3 ± 0.375+++

397.4 ± 1.446+++

130.7 ± 1.300+++

CisPT

9.122 ± 0.323***

94.22 ± 1.480***

92.60 ± 0.756***

109.9 ± 1.166***

74.85 ± 0.964***

AHE alone

18.28 ± 0.673+++

154.9 ± 0.409+++

139.5 ± 0.452+++

398.1 ± 1.379+++

130.9 ± 1.101+++

AHE (200) + CisPT

12.83 ± 0.145***,+++

122.2 ± 0.779***,+++

111.1 ± 0.288***,+++

218.2 ± 0.672***,+++

96.00 ± 1.134***,+++

AHE (400) + CisPT

17.13 ± 0.302+++,##

142.1 ± 1.146**,+++,##

133.1 ± 0.853*,+++,###

380.9 ± 0.610+++,###

126.3 ± 1.052+++,###

Sily + CisPT

17.00 ± 0.145+++

141.0 ± 1.201**,+++

132.8 ± 1.049 *,+++

381.5 ± 0.691+++

125.6 ± 0.985+++

  1. Data expressed as mean ± SEM (n = 8). Astericks *, **, *** indicted significant difference of final body weight of group Vs. Control group at p < 0.05, p < 0.001 and p < 0.0001 respectively, ++, +++ indicated significant difference of final body weight of group Vs. CisPT-treated group at p < 0.001 and p < 0.0001 respectively, ##, ### indicated significant difference of final body weight of AHE (200 mg/kg) + CisPT treated group Vs. AHE (400 mg/kg) + CisPT treated group at p < 0.001 and p < 0.0001 respectively. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters. (One-way ANOVA followed by Tukey’s multiple comparison tests). Sily-Silymarin