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Table 2 Effect of Cisplatin (CisPT) and different treatments of AHE on Brain POD, SOD, CAT, and QR levels

From: Reversal of cisplatin triggered neurotoxicity by Acacia hydaspica ethyl acetate fraction via regulating brain acetylcholinesterase activity, DNA damage, and pro-inflammatory cytokines in the rodent model

Treatment (mg/kg)

POD (U/min)

SOD (U/mg protein)

CAT (U/min)

QR (nM/min/mg protein)

Control

11.85 ± 0.130+++

1.812 ± 0.060+++

35.50 ± 0.289+++

93.49 ± 0.526+++

CisPT

5.170 ± 0.383**

0.541 ± 0.050***

18.43 ± 0.251***

63.55 ± 1.275***

AHE alone

11.30 ± 0.185+++

1.831 ± 0.071+++

35.93 ± 0.479+++

93.84 ± 0.140+++

AHE (200) + CisPT

8.010 ± 0.151**,+++

1.165 ± 0.098**,+++

26.96 ± 0.248***,+++

73.32 ± 0.667***,+++

AHE (400) + CisPT

10.14 ± 0.203+++,##

1.697 ± 0.083+++,##

30.08 ± 0.107*,+++,##

83.22 ± 0.491**,+++,##

Sily + CisPT

10.12 ± 0.196+++

1.675 ± 0.066+++

30.19 ± 0.335*,+++

83.11 ± 0.537 **,+++

  1. Data expressed as mean ± SEM (n = 8). Astericks *, **, *** indicted significant difference of final body weight of group Vs. Control group at p < 0.05, p < 0.001 and p < 0.0001 respectively, ++, +++ indicated significant difference of final body weight of group Vs. CisPT-treated group at p < 0.001 and p < 0.0001 respectively, ## indicated significant difference of final body weight of AHE (200 mg/kg) + CisPT treated group Vs. AHE (400 mg/kg) + CisPT treated group at p < 0.001. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters. (One-way ANOVA followed by Tukey’s multiple comparison tests). Sily-Silymarin